Research Strategies of Natural Products Biosynthesis Pathways and Key Enzymes in Medicinal Plants

doi:10.13560/j.cnki.biotech.bull.1985.2021-0949

Abstract

Abstract:

Natural products derived from medicinal plants are important sources of drug research and development. The traditional researches about natural products from medicinal plants mainly focus on their extraction and purification,chemical structure,biosynthesis and biological function. With the rapid development of genomics,bioinformatics,molecular biology,molecular genetics,synthetic biology and other disciplines and extensive cross integration among them,there are emerging opportunities for the natural products of medicinal plants. This paper systematically summarizes the research strategies of natural products biosynthesis and key enzymes in medicinal plants,included six aspects：speculation of natural products biosynthesis pathway,discovery and prediction of key enzymes in natural product biosynthesis,expression characteristics of enzymes,function of enzymes in vivo,catalytic characteristics of enzymes,analysis and optimization of enzyme structure and synthetic biology studies. Moreover,the trend of research strategies of natural products biosynthesis pathway and key enzymes in medicinal plants are prospected.

Key words: medicinal plants, natural products, key enzymes, biosynthesis pathway

ZHOU Zheng, LI Qing, CHEN Wan-sheng, ZHANG Lei. Research Strategies of Natural Products Biosynthesis Pathways and Key Enzymes in Medicinal Plants[J]. Biotechnology Bulletin, 2021, 37(8): 25-34.

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