The Composition and Function of Small RNA—Research Overview of Three Types of Endogenous Small RNA

Abstract

Abstract: There are many small non-coding RNA in the organisms. They through complete or incomplete complementary base pairingwith target mRNA, leading to mRNA breakage or translational repression, so as to achieve the purpose of the regulation of gene expression.These small RNA composed the highly complex RNA regulatory networks in cells, and play an important role in the physiological activity ofthe biological process of growth and development. Endogenous small RNA including miRNA, siRNA, and piRNA three categories, the articleoutlines three small RNA biogenesis, mechanism, and function research progress.

Key words: Small RNA , miRNA , siRNA , Mechanism , Function

Li Ze, Bai Helu. The Composition and Function of Small RNA—Research Overview of Three Types of Endogenous Small RNA[J]. Biotechnology Bulletin, 2013, 0(1): 25-30.

References

[1] Fire A, Xu S, Montgomery MK, et al. Potent and specific geneticinterference by double-stranded RNA in Caenorhabditis elegans[J].Nature, 1998, 391（6669）：806-811.
[2] Zamore PD, Tuschl T, Sharp PA, et al. RNAi ：double-stranded RNAdirects the ATP-dependent cleavage of mRNA at 21 to 23 nucleotideintervals[J]. Cell, 2000, 101（1）：25-33.
[3] Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammaliancells[J]. Nature, 2001, 411（6836）：494-498.
[4] Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronicgene lin-4 encodes small RNAs with antisense complementarity tolin-14[J]. Cell, 1993, 75（5）：843-854.
[5] Reinhart BJ, Slack FJ, Basson M, et al. The 21 nucleotide Let-7 RNAregulates developmental timing in Caenorhabditis elegans[J]. Nature,2000, 403 ：901-906.
[6] Lu JJ, LiaoWB, Peng M. The Progress of MicroRNA Research[J].Molecular Plant Breeding, 2006, 4（6）：73-77.
[7] 汤华. RNA 干扰原理与应用[M]. 北京：科学出版社, 2006.
[8] Hua YJ, Xiao HS. Progresses on the microRNA study[J]. ChineseBulletin of Life Sciences, 2005, 17（3）：278-281.
[9] 伍林涛, 阮颖, 彭琦, 等. miRNA 研究进展[J]. 作物研究,2006（5）：572-576.
[10] Bartel DP. MicroRNAs ：genomics, review ：biogenesis, mechanism,and function[J]. Cell, 2004, 116（2）：281-297.
[11] Pasquinell AE, Ruvkun G. Control of developmental timing bymicrornas and their targets[J]. Cell and Developmental Biology,2002. 18 ：495-513.
[12] Ambros V. The functions of animal microRNAs[J]. Nature,2004, 431 ：350-355.
[13] Yu Z, Li Z, Jolicoeur N, et al. Aberrant allele frequencies of the SNPslocated in microRNA target sites are potentially associated withhuman cancers[J]. Nucleic Acids Res, 2007, 35（13）：4535-4541.
[14] 何晨, 谭军, 陈薇. MicroRNA 的研究进展[J]. 生物技术通报,2006（1）：18-21.
[15] Kim VN. Sorting out small RNAs[J]. Cell, 2008, 133（1）：25-26.
[16] Pak J, Fire A. Distinct populations of primary and secondary effectorsduring RNAi in C. elegans[J]. Science, 2007, 315（5809）：241-244.
[17] Sijen T, Steiner FA, Thijssen KL, et al. Secondary siRNAs resultfrom unprimed RNA synthesis and form a distinct class[J].Science, 2007, 315（5809）：244-247.
[18] Lau NC, Seto AG, Kim J. Characterization of the piRNA complexfrom rat testes[J]. Science, 2006, 313（5785）：363-367.
[19] Aravin A, Gaidatzis D, Pfeffer S, et al. A novel class of small RNAsbind to MILI proteinin mouse testes[J]. Nature, 2006, 442（7099）：203-207.
[20] Girard A, Sachidanandam R, Hannon GJ, et al. Agermline specificclass of small RNAs binds mammalian Piwi proteins[J]. Nature,2006, 442（7099）：199-202.
[21] 黄雪梅, 张守涛. piRNA ：一类新的非编码小RNA[J]. 中国生物工程杂志, 2008, 28（8）：130-135.