Mechanism of Immuno-regulation Activity of Calreticulin

Abstract

Abstract: Calreticulin (CRT) is a 46 kD Ca2+-binding resident protein which regulates cellular Ca2+ concentration and enhances angtigen presentation and inhibits angiogenesis. The review has shown that calreticulin is involved in molecular mechanism of immuno-regulation activity of calreticulin by clearance of apoptotic cells and angtigen presentation and signal transduction and humoral immunity and is expected to provide theory and experiment foundation for the pathogenic mechanisms and immune interventions of CRT.

Key words: Calreticulin, Immuno-regulation, Molecular mechanism, Angtigen presentation

Wu Wei, Liu Chaoqi. Mechanism of Immuno-regulation Activity of Calreticulin[J]. Biotechnology Bulletin, 2013, 0(3): 44-47.

References

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