PI3K-Akt Signaling Pathway and Viral Infection

Abstract

Abstract: Many viruses have developed the ability to modulate key signaling pathways, and govern host cell functions to facilitate its proliferation. PI3K-Akt pathway is one of these key pathways which participate in host-pathogen interaction. Viruses take advantage of this pathway to create an environment favourable for its replication, resulting in dysfunction of the host cells, or even carcinogenesis. A thorough study on the roles of PI3K-Akt pathway in virus infection is of great significance to comprehensively understand pathogenesis, prevention and treatment of virus diseases. In this review, we summarize the recent advances in research on the regulation of PI3K-Akt signaling during virus infection.

Key words: PI3K-Akt, Virus Infection, Immunity, Carcinogenesis

Liu Rongdiao, Ruan Lingwei. PI3K-Akt Signaling Pathway and Viral Infection[J]. Biotechnology Bulletin, 2013, 0(6): 53-62.

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