Calreticulin and Apoptosis Mediated by Endoplasmic Reticulum Stress

Abstract

Abstract: Calreticulin（CRT）is a 46 kD endoplasmic reticulum luminal protein and has various biological functions including chaperone activity, regulation of Ca2+ homeostasis, cell apoptosis. Endoplasmic reticulum stress（ERS）is pathological changes of subcellular organelles, early time of ERS can be reversed, as the time go, cellular damage is more and more serious result in apoptosis. New research shows that CRT plays an important role in apoptosis mediated by endoplasmic reticulum stress. This review explained clearly the interrelation between them and was expected to provide some information for the study.

Key words: Calreticulin, Chaperone, Endoplasmic reticulum stress, Cell apoptosis

Wu Wei Liu Chaoqi. Calreticulin and Apoptosis Mediated by Endoplasmic Reticulum Stress [J]. Biotechnology Bulletin, 2013, 0(10): 24-27.

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