生物技术通报 ›› 2022, Vol. 38 ›› Issue (9): 84-95.doi: 10.13560/j.cnki.biotech.bull.1985.2022-0497

• 细菌耐药性专题(专题主编: 刘雅红 教授 孙坚 教授) • 上一篇    下一篇

氟喹诺酮类抗生素及耐药基因污染控制的研究进展

李柳1,2,3(), 穆迎春2,3, 刘璐2,3, 张洪玉2, 徐锦华2,3, 杨臻2,3, 乔璐2,3, 宋金龙2,3()   

  1. 1.上海海洋大学食品学院,上海 200120
    2.中国水产科学研究院,北京 100141
    3.农业农村部水产品质量安全控制重点实验室,北京 100141
  • 收稿日期:2022-04-22 出版日期:2022-09-26 发布日期:2022-10-11
  • 作者简介:李柳,女,硕士研究生,研究方向:水产微生物;E-mail: 1410150575@qq.com
  • 基金资助:
    中央级公益性科研院所基本科研业务费(2021A003);农业农村部淡水渔业健康养殖重点实验室开放课题(ZJK202101);财政部和农业农村部:国家现代农业产业技术体系资助(CARS-48)

Research Progress on Contamination Control of Fluoroquinolone Antibiotics and Drug Resistance Genes

LI Liu1,2,3(), MU Ying-chun2,3, LIU Lu2,3, ZHANG Hong-yu2, XU Jin-hua2,3, YANG Zhen2,3, QIAO Lu2,3, SONG Jin-long2,3()   

  1. 1. College of Food Science and Technology,Shanghai Ocean University,Shanghai 200120
    2. Chinese Academy of Fishery Sciences,Beijing 100141
    3. Key Laboratory of Control of Quality and Safety for Aquatic Products,Ministry of Agriculture and Rural Affairs,Beijing 100141
  • Received:2022-04-22 Published:2022-09-26 Online:2022-10-11

摘要:

氟喹诺酮类抗生素属于喹诺酮类抗生素,是一类人畜通用的抗生素。近年来,被广泛应用于人类和畜牧、水产等养殖业领域,然而其大量使用,造成在环境中的不断残留和累积,给自然环境和人类健康造成了较大威胁。现有研究表明,微生物降解是有效去除氟喹诺酮类抗生素残留污染的有效方法之一。本文总结和介绍了近年来氟喹诺酮类抗生素微生物降解单株菌和混合菌群、微生物降解酶、降解途径以及微生物降解氟喹诺酮类抗生素的实际应用,并对目前氟喹诺酮类抗生素微生物降解研究中存在的问题进行了分析,以及对未来氟喹诺酮类抗生素微生物降解研究的重点进行了探讨,以期为后续的研究提供参考。

关键词: 氟喹诺酮类抗生素, 降解菌, 降解酶, 降解途径

Abstract:

Fluoroquinolone antibiotics belong to quinolone antibiotics,is a kind of common antibiotics for human and livestock. In recent years,it has been widely used in human and animal husbandry,aquaculture and other aquaculture fields. However,its massive use has caused continuous residue and accumulation in the environment,posing a great threat to the natural environment and human health. Existing studies show that microbial degradation is one of the effective methods to remove the residual contamination of fluoroquinolone antibiotics. This paper summarized and introduced the practical application of fluoroquinolone antibiotics in microbial degradation of single strain and mixed bacteria,microbial degradation enzymes,degradation pathways and fluoroquinolone antibiotics in recent years,and analyzed the existing issues in the study of fluoroquinolone antibiotics microbial degradation. In addition,the paper also discussed the research focus of fluoroquinolone antibiotics microbial degradation in the future,aiming to provide reference for the follow-up research.

Key words: fluoroquinolone antibiotics, degradation bacteria, degradation enzyme, degradation pathway