卵母细胞裂解液逆转化体细胞为多能干细胞的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2014.12.004

生物技术通报 ›› 2014, Vol. 0 ›› Issue (12): 24-28.doi: 10.13560/j.cnki.biotech.bull.1985.2014.12.004

卵母细胞裂解液逆转化体细胞为多能干细胞的研究进展

沈心怡 ,宋坤, 杨利珊, 肖雄 ,张大鹏, 杨波 ,李跃民

重庆市牧草与草食家畜重点实验室西南大学动物科技学院，重庆 400715

收稿日期:2014-03-22 出版日期:2014-12-08 发布日期:2014-12-12
作者简介:沈心怡，女，硕士研究生，研究方向:临床兽医学;E-mail:564169219@qq.com
基金资助:
国家级大学生创新创业训练计划(201210635016)

Progress on Oocytes Extracts-mediated Derivation of Pluripotent Stem Cells from Somatic Cells

Shen Xinyi, Song Kun, Yang Lishan, Xiao Xiong, Zhang Dapeng, Yang Bo, Li Yuemin

(Chongqing Key Lab of Forage & Herbivore, College of Animal Science and Technology, Southwest University, Chongqing 400715)

Received:2014-03-22 Published:2014-12-08 Online:2014-12-12

摘要/Abstract

摘要： 采用卵母细胞裂解液重编程体细胞为多能干细胞是体细胞重编程的一个新思路，该方法主要是通过体细胞与卵母细胞裂解液的共孵育，使得体细胞在形态、基因和功能等方面发生改变，趋向于胚胎干细胞的方向发展。就卵母细胞裂解液重编程体细胞的研究现状、影响因素及存在的问题进行综述。

关键词: 卵母细胞, 卵母细胞裂解液, 重编程, 体细胞, 多能干细胞

Abstract: Oocytes extracts-mediated derivation of pluripotent stem cells from somatic cells provides a new way for reprogramming. Morphologies, genes, and functions of somatic cells will be changed and somatic cells tend to be reprogrammed into stem cells after in-vitro co-incubation with oocytes extracts. The present situation, influence factors, existing problems, and prospects of somatic cells reprogramming using oocytes extracts were described in this review.

Key words: Oocytes, Oocytes extracts, Reprogramming, Somatic cells, Pluripotent stem cells

沈心怡 ,宋坤, 杨利珊, 肖雄 ,张大鹏, 杨波 ,李跃民. 卵母细胞裂解液逆转化体细胞为多能干细胞的研究进展[J]. 生物技术通报, 2014, 0(12): 24-28.

Shen Xinyi, Song Kun, Yang Lishan, Xiao Xiong, Zhang Dapeng, Yang Bo, Li Yuemin. Progress on Oocytes Extracts-mediated Derivation of Pluripotent Stem Cells from Somatic Cells[J]. Biotechnology Bulletin, 2014, 0(12): 24-28.

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卵母细胞裂解液逆转化体细胞为多能干细胞的研究进展

Progress on Oocytes Extracts-mediated Derivation of Pluripotent Stem Cells from Somatic Cells

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