家禽卵泡闭锁机制的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2019-0595

摘要/Abstract

摘要： 家禽卵泡闭锁是一种受多种机制共同调控卵泡退化的过程,与家禽的繁殖性能密切相关。近年来,随着分子技术的快速发展,针对家禽卵泡细胞的凋亡和自噬引起卵泡闭锁的研究取得巨大进展。综述了家禽卵泡内细胞凋亡与自噬对家禽卵泡闭锁调控机制,讨论了卵泡细胞凋亡与自噬引起卵泡闭锁的意义及存在的问题。通过对家禽卵泡闭锁机制的研究,以期为家禽产蛋性能的充分利用和挖掘提供理论依据。

关键词: 家禽, 颗粒细胞, 凋亡, 自噬, 卵泡闭锁, 调控机制

Abstract: Poultry follicular atresia is a process that regulates follicular degeneration by a variety of mechanisms and is closely related to the reproductive performance of poultry. In recent years,with the rapid development of molecular technology,great progress has been made in the study of follicular atresia caused by apoptosis and autophagy in poultry follicular cells. In this paper,the regulation of apoptosis and autophagy for poultry follicular atresia in poultry follicles are reviewed. Then the significance and problems of follicular cell apoptosis and autophagy caused by follicular atresia are discussed. It provides a theoretical basis for the full utilization and excavation of poultry laying performance through the study of the mechanism of poultry follicle atresia.

Key words: poultry, granulosa cell, apoptosis, autophagy, follicular atresia, regulation mechanism

邹坤, 路丽丽, Collins Asiamah Amponsah, 薛缘, 张少伟, 苏瑛, 赵志辉. 家禽卵泡闭锁机制的研究进展[J]. 生物技术通报, 2020, 36(4): 185-191.

ZOU Kun, LU Li-li, Collins Asiamah Amponsah, XUE Yuan, ZHANG Shao-wei, SU Ying, ZHAO Zhi-hui. Research Progress on Mechanism of Poultry Follicular Atresia[J]. Biotechnology Bulletin, 2020, 36(4): 185-191.

参考文献

[1] Gilbert AB, Evans AJ, Perry MM, et al.A method for separating the granulosa cells, the basal lamina and the theca of the preovulatory ovarian follicle of the domestic fowl(Gallus domesticus)[J]. J Reprod Fertil, 1977, 50(1):179-181.
[2] Zhang J, Xu Y, Liu H, et al.MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis[J]. Rep Bio and End, 2019, 17(1):9.
[3] 李碧春, 秦洁. 雌禽生殖生理研究进展[J]. 中国畜牧兽医, 2006, 33(1):36-39.
[4] 陈秀萍, 姜勋平, 丁家桐, 等. 鹅卵泡颗粒细胞凋亡及其与生殖激素间的关系[J]. 畜牧兽医学报, 2006, 37(10):982-986.
[5] Jing Y, Lou Y, Ke H, et al.Goose broodiness is involved in granulosa cell autophagy and homeostatic imbalance of follicular hormones[J]. Poult Sci, 2016, 95(5):1156-1159.
[6] Meng L, Jan SZ, Hamer G, et al.Preantral follicular atresia occurs mainly through autophagy, while antral follicles degenerate mostly through apoptosis[J]. Biol Reprod, 2018, 99(1):853-863.
[7] 金艳梅. 鸡等级前卵泡颗粒细胞发育的激素和营养调控及机理研究[D]. 杭州:浙江大学, 2007.
[8] Gupta SK, Gilbert AB, Walker MA.Histological study of follicular atresia in the ovary of the domestic hen(Gallus domesticus)[J]. Journal of Reproduction & Fertility, 1988, 82(1):219-225.
[9] 黄正洋. 表皮生长因子参与鹅卵泡颗粒细胞增殖调控机理的研究[D]. 扬州:扬州大学, 2016.
[10] Lin JX, Jia YD, Zhang CQ.Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles[J]. J Zhejiang Univ Sci B, 2011, 12(11):875-883.
[11] Johnson AL, Woods DC.Dynamics of avian ovarian follicle development:Cellular mechanisms of granulosa cell differentiation[J]. Gen & Comp Endocrinol, 2009, 163(1):12-17.
[12] 梁学超, 蒋明, 等. 猪卵巢发育的组织学变化及卵泡闭锁规律研究[J]. 畜牧兽医学报, 2017, 48(10):1863-1870.
[13] 何宝祥, 郑喜邦, 等. 水牛有腔卵泡颗粒细胞凋亡的生物形态学特征[J]. 畜牧兽医学报, 2006, 37(11):1209-1216.
[14] Choi JY, Jo MW, Lee EY, et al.Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells[J]. Fertility & Sterility, 2011, 95(4):1482-1486.
[15] 郭燕君, 徐营, 刘胜兵, 等. LC3蛋白在小鼠卵泡颗粒细胞中的表达及定位研究[J]. 中国病理生理杂志, 2017, 33(9):1690-1695.
[16] 罗茜, 陈伟, 郑春田, 等. 家禽卵泡颗粒细胞体外培养方法研究进展[J]. 动物营养学报, 2016, 28(9):2681-2686.
[17] Chen F, Jiang X, Chen X, et al.Effects of downregulation of inhibin α gene expression on apoptosis and proliferation of goose granulosa cells[J]. J Genetics Genomics, 2007, 34(12):1106-1113.
[18] 宋艳画, 宋善道, 张家骅. 原始卵泡形成和发育调节机制研究进展[J]. 动物医学进展, 2006, 27(3):30-33.
[19] 应诗家, 于建宁, 施振旦. GDF9/BMP15对卵泡发育的调控[J]. 家畜生态学报, 2013, 34(9):8-12.
[20] Yongje R.体外成熟牛卵母细胞BMP15和GDF9的表达及其对卵丘细胞凋亡的影响[D]. 北京:中国农业科学院, 2015.
[21] 李悦, 计红, 薛琳琳, 等. 不同培养时间对鸡卵泡颗粒细胞孕酮、雌激素分泌水平及FSHR、LHR基因表达的影响[J]. 中国应用生理学杂志, 2017, 33(2):174-178.
[22] Woods DC, Johnson AL.Regulation of follicle-stimulating hormone-receptor messenger RNA in hen granulosa cells relative to follicle selection[J]. Biology of Reproduction, 2005, 72(3):643-650.
[23] Rangel PL, Gutierrez CG.Reproduction in hens:Is testosterone necessary for the ovulatory process?[J]. General & Comparative Endocrinology, 2014, 203(2):50-61.
[24] Johnson AL.Ovarian follicle selection and granulosa cell differentiation[J]. Poultry Science, 2015, 94(4):781-789.
[25] Wang J, Zhao C, Li J, et al.Transcriptome analysis of the potential roles of FOXL2 in chicken pre-hierarchical and pre-ovulatory granulosa cells[J]. Comparative Biochemistry & Physiology Part D, 2017, 21(5):56-66.
[26] Nepomuceno AI, Muddiman DC, Petitte JN.Global proteomic analysis of functional compartments in immature avian follicles using laser microdissection coupled to LC-MS/MS[J]. Journal of Proteome Research, 2015, 14(9):3912-3923.
[27] Akazome Y, Abe T, Mori T.Differentiation of chicken gonad as an endocrine organ:expression of LH receptor, FSH receptor, cytochrome P450c17 and aromatase genes[J]. Biol Reprod, 2002, 123(5):721-728.
[28] 李晓雯, 郎朗, 季宇彬, 等. 卵泡刺激素促进卵巢颗粒细胞增殖分化的信号通路的研究进展[J]. 北京联合大学学报, 2012, 26(4):46-50.
[29] Ghanem K, Johnson AL.Follicle dynamics and granulosa cell differentiation in the turkey hen ovary[J]. Poultry Science, 2018, 97(10):3755-3761.
[30] Wen R, Hu S, Xiao Q, et al.Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells through the PI3K/Akt/mTOR signaling pathway[J]. J Steroid Bioch & Mol Bio, 2015, 149(70):9-15.
[31] 魏泽辉, 贾存灵. 家禽卵泡选择过程中颗粒细胞的分子调控机制[J]. 中国家禽, 2017, 39(21):1-5.
[32] Du X, Pan Z, Li Q, et al.Smad4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis[J]. Cell Death & Dis, 2018, 9(2):151-158.
[33] Ramasamy M, Sreesujatha. Regulation of ovarian follicular atresia through apoptotic process in Japanese Quail(Coturnix coturnix japonica)[J]. Internation Journal of Advacne Research in Biological Sciences, 2014, 9(1):326-330.
[34] Johnson AL.The avian ovary and follicle development:Some comparative and practical insights[J]. Turkish Journal of Veterinary & Animal Sciences, 2014, 38(6):660-669.
[35] Wang Y, Chen Q, Liu Z, et al.Transcriptome analysis on single small yellow follicles reveals that wnt4 is involved in chicken follicle selection[J]. Front End, 2017, 8(3):17-21.
[36] 林金杏. 局部性促生长因子对鸡卵泡发育的调控及其机理的研究[D]. 杭州:浙江大学, 2011.
[37] Gan X, Chen D, Deng Y, et al. Establishment of anin vitroculture model of theca cells from hierarchical follicles in ducks[J]. Bioscience Reports, 2017, 37(3):BSR20160491.
[38] Lee KA, Bahr JM.Utilization of substrates for testosterone and estradiol-17 beta production by small follicles of the chicken ovary[J]. Domest Anim Endocrinol, 1994, 11(3):307-314.
[39] Kim D, Ocón-Grove O, Johnson AL.Bone morphogenetic protein 4 supports the initial differentiation of hen(Gallus gallus)granulosa cells[J]. Biology of Reproduction, 2013, 88(6):161.
[40] Nitta H, Osawa Y, Bahr JM.Two populations of steroidogenic cells in the theca layer of chicken ovarian follicles[M]. Serono Symposia USA, 1991.
[41] Vitt UA, Mcgee EA, Hayashi M, et al.In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell marker CYP17 in ovaries of immature rats[J]. Endocrinology, 2000, 141(10):3814-3820.
[42] Rangel PL, Rodríguez A, Gutierrez CG.Testosterone directly induces progesterone production and interacts with physiological concentrations of LH to increase granulosa cell progesterone production in laying hens(Gallus domesticus)[J]. Animal Reproduction Science, 2007, 102(1):56-65.
[43] Hattori K, Orisaka M, Fukuda S, et al.Luteinizing hormone facilitates antral follicular maturation and survival via thecal paracrine signaling in cattle[J]. Endocrinology, 2018, 159(6):2337-2347.
[44] Lin X, Liu X, Ma Y, et al.Coherent apoptotic and autophagic activities involved in regression of chicken postovulatory follicles[J]. Aging, 2018, 10(4):819-832.
[45] Choi J, Jo M, et al.AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia[J]. Reproduction, 2014, 147(1):73-80.
[46] Zhou J, Yao W, Li C, et al.Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells[J]. Cell Death & Disease, 2017, 8(8):e3001.
[47] Kim C, Park JM, Song Y, et al.HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy[J]. Aging cell, 2019(1):e12909.
[48] Siddiqui FA, Prakasam G, Chattopadhyay S, et al.Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition[J]. Scientific Reports, 2018, 8(1):8323.
[49] Gao H, Lin L, Haq IU, et al.Inhibition of NF-κB promotes autophagy via JNK signaling pathway in porcine granulosa cells[J]. Biochemical & Biophysical Research Communications, 2016, 473(1):311-316.
[50] 覃芳, 张智博. JNK信号通路与自噬的研究进展[J]. 中南大学学报:医学版, 2015, 40(9):1035-1038.
[51] Du L, Gu T, et al.Transcriptome profiling to identify key mediators of granulosa cell proliferation upon FSH stimulation in the goose(Anser cygnoides)[J]. British Poult Sci, 2018, 59(4):416-421.
[52] Yu J, Lou Y, He K, et al.Goose broodiness is involved in granulosa cell autophagy and homeostatic imbalance of follicular hormones[J]. Poult Sci, 2016, 95(5):1156-1162.
[53] Lou Y, Yu W, Han L, et al.ROS activates autophagy in follicular granulosa cells via mtor pathway to regulate broodiness in goose[J]. Ani Rep Sci 2017, 185(1):37-103.
[54] Ming S, Yan C, Yi J, et al.Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy:Implication of an antioxidation-independent mechanism[J]. Redox Bio, 2018, 18(1):38-57.
[55] Cao Y, Shen M, Jiang Y, et al.Melatonin reduces oxidative damage in mouse granulosa cells via restraining JNK-dependent autophagy[J]. Reproduction, 2018, 155(3):307-319.
[56] Kang B, Wang XX, Xu QL, et al. Effect of 3-NPA inducing oxidative stress and apoptosis of granulosa cells in geese[J]. Biosci Rep, 2018, 38(5). pii:BSR20180274.
[57] Yamamoto Y, Kuwahara A, et al.Tumor necrosis factor alpha inhibits ovulation and induces granulosa cell death in rat ovaries[J]. Reprod Med Biol, 2015, 14(3):107-115.
[58] 曹伟. 鹅Dicer基因克隆及其在卵泡中的发育性表达研究[D]. 雅安:四川农业大学, 2012.
[59] Shen M, Li T, et al.Dynamic expression and functional analysis of circRNA in granulosa cells during follicular development in chicken[J]. BMC Genomics, 2019, 20(1):96-102.
[60] Worku T, Rehman Z, Talpur H, et al.MicroRNAs:new insight in modulating follicular atresia:a review[J]. International Journal of Molecular Sciences, 2017, 18(2):E333.

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