C 型尿钠肽在动物繁殖过程中的作用研究进展

生物技术通报 ›› 2013, Vol. 0 ›› Issue (1): 36-40.

C 型尿钠肽在动物繁殖过程中的作用研究进展

贾振伟^1,2，张家新³,安磊² ,吴中红² ,田见晖²

1. 内蒙古民族大学动物科技学院，通辽 028000 ；2. 中国农业大学动物科技学院，北京 100193 ；3. 内蒙古农业大学动物科技学院，呼和浩特 010018

收稿日期:2012-11-12 修回日期:2013-01-31 出版日期:2013-01-30 发布日期:2013-01-30
作者简介:贾振伟，男，博士，讲师，研究方向：配子与胚胎生物技术；E-mail ：zhenwei1999@sina.com
基金资助:
内蒙古民族大学博士科研启动基金项目（BS299）

Advances on the Role of C-type Natriuretic Peptide in Regulating Animal Reproduction Processes

Jia Zhenwei^1,2,Zhang Jiaxin³, An Lei²,Wu Zhonghong², Tian Jianhui²,

1. College of Animal Science and Technology，Inner Mongolia University for the Nationalities，Tongliao 028000;
2. College of Animal Science and Technology，China Agricultural University，Beijing 100193 ；3. College of Animal Science and Technology，Inner Mongolia Agricultural University，Huhhot 010018

Received:2012-11-12 Revised:2013-01-31 Published:2013-01-30 Online:2013-01-30

摘要/Abstract

摘要： C 型尿钠肽（CNP）为尿钠肽家族成员之一，作为自分泌及旁分泌因子不仅具有维持心血管系统功能稳态、调控细胞增殖及促进骨骼生长等功能，并且在动物繁殖过程方面具有重要的作用。近年研究揭示CNP 是小鼠体内减数分裂抑制物质，而且CNP 能够促进卵泡发育，增加促性腺激素刺激后的排卵数量。基于此，CNP 在用作生理性的减数分裂抑制剂增强卵母体外发育及提高家畜的超排效率方面具有重要的应用前景。因此，综述CNP 结构、作用机制、在动物繁殖过程的作用及应用前景。

关键词: C , 型钠肽 , 动物繁殖 , 作用

Abstract: C-type natriuretic peptide(CNP), a member of the natriuretic peptide family of structurally related peptides, is a autocrine /paracrine growth factor with important roles in cardiovascular homeostasis, regulation of cell proliferation and skeletal development ； moreover,CNP also plays a key role in modulating animal reproductive processes. Notably, recent studies have revealed that CNP acts as a regulator toinhibit meiotic resumption in mouse oocytes in vivo ； additionally, CNP can enhances superovulation response by the stimulation of folliculardevelopment prior to gonadotropins treatment. In light of the findings above, CNP may be of special importance in the promotion of oocytedevelopment in vitro as one meiotic inhibitor, as well as the improvement of superovulation efficiency in domestic animals. Hence, this paperreviewed the structure of CNP, its role as one of functional molecules that modulate reproductive processes in animals and its potencial value.

Key words: C-type natriuretic peptide , Animal reproduction , Role

贾振伟, 张家新, 安磊, 吴中红, 田见晖. C 型尿钠肽在动物繁殖过程中的作用研究进展[J]. 生物技术通报, 2013, 0(1): 36-40.

Jia Zhenwei, Zhang Jiaxin, An Lei, Wu Zhonghong, Tian Jianhui,. Advances on the Role of C-type Natriuretic Peptide in Regulating Animal Reproduction Processes[J]. Biotechnology Bulletin, 2013, 0(1): 36-40.

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