细菌群体感应及其在病原菌防治中的应用

doi:10.13560/j.cnki.biotech.bull.1985.2015.01.005

摘要/Abstract

摘要： 细菌分泌一种或多种化学信号分子，这些化学信号分子作为诱导因子感知和判断菌群密度和周围环境的变化。当菌群达到一定阈值时会启动一系列相关基因的表达以调控菌体的群体行为，细菌的这种生理行为称为群体感应。大量的研究表明，不同类型的细菌具有不同的群体感应系统。群体感应机制广泛存在于病原菌中，并与其侵染过程、毒力基因表达及致病性密切相关。利用这种群体感应机制作为靶点进行病原菌的防治是医学领域广泛关注的问题。在此就细菌群体感应及其在病原菌防治中的应用进行阐述。

关键词: 细菌, 群体感应, 自身诱导因子, 调控, 病原菌防治

Abstract: Bacteria releases one or several chemical molecules served as signal to estimate the density of bacteria and sense the change of environment. This chemical communication, called as “quorum sensing”（QS）is defined as a density dependent mechanism by which bacteria coordinate expression of specific target genes in response to a critical concentration of signal molecules. A many of studies had showed that the construction of various QS system depends on the type of bacteria. QS system exists widely in pathogenic bacteria, which build up the capability of infection, expression of toxic genes and pathogenesis. Therefore, it is a concerned topic in medicine realm that prevents and cures the diseases caused by pathogenic bacteria by targeting the QS system. Here, this review discussed the QS and its application in preventing and therapeutic effect for pathogenic bacteria.

Key words: bacteria, quorum sensing, autoinducer, control, pathogen therapeutic

梁心琰,阮海华. 细菌群体感应及其在病原菌防治中的应用[J]. 生物技术通报, 2015, 31(1): 33-38.

Liang Xinyan, Ruan Haihua. Quorum Sensing and Its Application in Preventing and Therapeutic Effect for Pathogenic Bacteria[J]. Biotechnology Bulletin, 2015, 31(1): 33-38.

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