几种用于寻找新型天然活性物质的开放型代谢组学数据库介绍

生物技术通报 ›› 2016, Vol. 32 ›› Issue (12): 29-33.

几种用于寻找新型天然活性物质的开放型代谢组学数据库介绍

张小蒙¹,孙明慧¹,李艳萍¹,李凤¹,卓微伟¹,周敏²

1. 盐城卫生职业技术学院，盐城 224005；
2. 盐城市第三人民医院，盐城 224001

收稿日期:2016-05-13 出版日期:2016-12-25 发布日期:2016-12-07
作者简介:张小蒙，男，硕士，研究方向：微生物代谢组学；E-mail：zxm_0305@163.com
基金资助:
江苏省大学生实践创新训练项目（201512682008Y），江苏高校品牌专业建设工程项目（PPZY2015A097）

The Introduction of Open Metabolomics Database Used for Looking for Novel Natural Active Substances

ZHANG Xiao-meng¹,SUN Ming-hui¹,LI Yan-ping¹,LI Feng¹,ZHUO Wei-wei¹,ZHOU Min²

1. College of Pharmacy，Yancheng Institute of Health Sciences，Yancheng 224005；
2. Department of Dermatology，Yancheng Third People’s Hospital，Yancheng 224001

Received:2016-05-13 Published:2016-12-25 Online:2016-12-07

摘要/Abstract

摘要： 经过长时间的探索和积累，人们已经建立了许多代谢组学数据库，这些数据库虽然所用到的技术手段不尽相同、所收集和公开的数据也存在差异，但是都有各自的特点和用处，同时也有各自的缺点与不足。主要介绍几种用于寻找新型天然活性物质的开放型代谢组学数据库，主要涉及数据库建立的技术手段、数据库包含数据的多少、如何接入查找等方面，同时也给出一些改进的意见，希望以后可以更加完善。

关键词: 天然活性物质, 高效气相, 高效液相, 质谱, 核磁共振, 代谢组学

Abstract: A lot of metabolomics database have been established after a long exploration and accumulation，they all have their own pros and cons though these databases are different on technical methods as well as collected and published data. This paper introduces several open metabolomics databases used for looking for novel natural active substances，mainly focusing on the technologies for establishing databases，the amount of data in databases，and how to access databases and seek information，etc. Concurrently，we also give some improvement suggestions for perfecting these databases in the future.

Key words: natural active substances, efficient gas phase, high performance liquid phase, mass spectrometry, nuclear magnetic resonance（NMR）, metabolomics

中图分类号:

10.13560/j.cnki.biotech.bull.1985.2016.12.006

张小蒙,孙明慧,李艳萍,李凤,卓微伟,周敏. 几种用于寻找新型天然活性物质的开放型代谢组学数据库介绍[J]. 生物技术通报, 2016, 32(12): 29-33.

ZHANG Xiao-meng,SUN Ming-hui,LI Yan-ping,LI Feng,ZHUO Wei-wei,ZHOU Min. The Introduction of Open Metabolomics Database Used for Looking for Novel Natural Active Substances[J]. Biotechnology Bulletin, 2016, 32(12): 29-33.

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