植物JAZ蛋白的功能概述

摘要/Abstract

摘要： 茉莉酸作为重要的植物激素，在植物生长、繁殖和抗逆等诸多方面起重要的作用。茉莉酸途径的抑制因子JAZ（Jasmonate ZIM-domain，JAZ）蛋白（JAZs）是调节茉莉酸（JA）激素应答的关键因子，在没有JA存在时，JAZs抑制DNA-结合转录因子活性，从而调控JA应答基因转录；当有JA存在时，JAZs和冠菌素不敏感1（Coronatine insensitive 1，COI1）依赖JA分子发生互作，复合体被SCF^COI1识别并进入26S蛋白酶解途径降解，释放的转录因子启动JA应答基因转录。随着研究的深入，发现JAZs可以与许多转录因子互作，不仅调控了JA信号响应，还参与了其他激素信号通路。对JAZs的互作机制进行描述，阐述JAZs在植物激素调控网络中的作用。

关键词: JAZs, TIFY, 茉莉酸

Abstract: Jasmonates（JA）as an important phytohormone regulates many aspects of plant development, reproduction, and defence. Within the JA signaling cascades, jasmonate zim-domain（JAZ）proteins that are triggered by jasmonates play a central role. JAZ proteins regulate JA-responsive gene transcription by inhibiting DNA-binding transcription factors（TFs）in the absence of JA. However, in the presence of JA, JAZ proteins interact in a hormone-dependent manner with Coronatine Insensitive 1（COI1）. After recognition component of the E3 ubiquitin ligase SCFCOI1, as a result, JAZ proteins are ubiquitinated and subsequently degraded in the 26S proteasome, releasing TFs from inhibition and activating JA-responsive gene transcription. This conclusion indicate that JAZ proteins, which function as transcriptional repressors of the JA signaling response, are not merely regulators of the JA signaling pathway, but, through interaction with other proteins, also serve as signaling hubs in the wider hormone regulatory network, plays important roles in plants..

Key words: JAZs, TIFY, Jasmonates

孙程, 周晓今, 陈茹梅, 范云六, 王磊. 植物JAZ蛋白的功能概述[J]. 生物技术通报, 2014, 0(6): 1-8.

Sun Cheng, Zhou Xiaojin, Chen Rumei, Fan Yunliu, Wang Lei. Comprehensive Overview of JAZ Proteins in Plants[J]. Biotechnology Bulletin, 2014, 0(6): 1-8.

参考文献

[1] Tiryaki I, Staswick PE. An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1[J] . Plant Physiology, 2002, 130：887-894.
[2] Pré M, Atallah M, Champion A, et al. The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense[J] . Plant Physiology, 2008, 147：1347-1357.
[3] Zhu Z, An F, Feng Y, et al. Derepression of ethylene-stabilized transcription factors（EIN3/EIL1）mediates jasmonate and ethylene signaling synergy in Arabidopsis[J] . Proc Natl Acad Sci USA, 2011, 108：12539-12544.
[4] Adams E, Turner J. COI1, a jasmonate receptor, is involved in ethylene-induced inhibition of Arabidopsis root growth in the light[J] . Journal of Experimental Botany, 2010, 61：4373-4386.
[5] Navarro L, Bari R, Achard P, et al. DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling[J] . Curr Biol, 2008, 18：650-655.
[6] Hou X, Lee LYC, Xia K, et al. DELLAs modulate jasmonate signaling via competitive binding to JAZs[J] . Developmental Cell, 2010, 19：884-894.
[7] Ren C, Han C, Peng W, et al. A leaky mutation in DWARF4 reveals an antagonistic role of brassinosteroid in the inhibition of root growth by jasmonate in Arabidopsis[J] . Plant Physiology, 2009, 151：1412-1420.
[8] Feys BJ, Benedetti CE, Penfold CN, Turner JG. Arabidopsis mutants selected for resistance to the phytotoxin coronatine are male sterile, insensitive to methyl jasmonate, and resistant to a bacterial pathogen[J] . The Plant Cell Online, 1994, 6：751-759.
[9] Xie DX, Feys BF, James S, et al. COI1：an Arabidopsis gene required for jasmonate-regulated defense and fertility[J] . Science, 1998, 280：1091-1094.
[10] Turner JG, Ellis C, Devoto A. The jasmonate signal pathway[J] . The Plant Cell Online, 2002, 14：S153-S164.
[11] Xu L, Liu F, Lechner E, et al. The SCFCOI1 ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis[J] . The Plant Cell Online, 2002, 14：1919-1935.
[12] Stintzi A. The Arabidopsis male-sterile mutant, opr3, lacks the 12-oxophytodienoic acid reductase required for jasmonate synthesis[J] . Proceedings of the National Academy of Sciences, 2000, 97：10625-10630.
[13] Mandaokar A, Thines B, Shin B, et al. Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling[J] . Plant J, 2006, 46：984-1008.
[14] Shikata M, Matsuda Y, Ando K, et al. Characterization of Arabidopsis ZIM, a member of a novel plant-specific GATA factor gene family[J] . Journal of Experimental Botany, 2004, 55：631-639.
[15] Derelle E, Ferraz C, Rombauts S, et al. Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features[J] . Proc Natl Acad Sci USA, 2006, 103：11647-11652.
[16] Vanholme B, Grunewald W, Bateman A, et al. The tify family previously known as ZIM[J] . Trends Plant Sci, 2007, 12：239-244.
[17] Bai Y, Meng Y, Huang D, et al. Origin and evolutionary analysis of the plant-specific TIFY transcription factor family[J] . Genomics, 2011, 98：128-136.
[18] Kazan K, Manners JM. JAZ repressors and the orchestration of phytohormone crosstalk[J] . Trends Plant Sci, 2012, 17：22-31.
[19] Chini A, Fonseca S, Chico JM, et al. The ZIM domain mediates homo-and heteromeric interactions between Arabidopsis JAZ proteins[J] . The Plant Journal, 2009, 59：77-87.
[20] Chung HS, Howe GA. A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis[J] . The Plant Cell Online, 2009, 21：131-145.
[21] Pauwels L, Barbero GF, Geerinck J, et al. NINJA connects the co-repressor TOPLESS to jasmonate signalling[J] . Nature, 2010, 464：788-791.
[22] Thines B, Katsir L, Melotto M, et al. JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling[J] . Nature, 2007, 448：661-665.
[23] Song S, Qi T, Huang H, et al. The jasmonate-ZIM domain proteins interact with the R2R3-MYB transcription factors MYB21 and MYB24 to affect jasmonate-regulated stamen development in Arabidopsis[J] . The Plant Cell Online, 2011, 23：1000-1013.
[24] Grunewald W, Vanholme B, Pauwels L, et al. Expression of the Arabidopsis jasmonate signalling repressor JAZ1/TIFY10A is stimulated by auxin[J] . EMBO Reports, 2009, 10：923-928.
[25] Berger S, Bell E, Mullet JE. Two methyl jasmonate-insensitive mutants show altered expression of AtVsp in response to methyl jasmonate and wounding[J] . Plant Physiology, 1996, 111：525-531.
[26] Lorenzo O, Chico JM, Sánchez-Serrano JJ, Solano R. JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis[J] . The Plant Cell Online, 2004, 16：1938-1950.
[27] Chini A, Fonseca S, Fernandez G, et al. The JAZ family of repressors is the missing link in jasmonate signalling[J] . Nature, 2007, 448：666-671.
[28] Yan Y, Stolz S, Chételat A, et al. A downstream mediator in the growth repression limb of the jasmonate pathway[J] . Science Signaling, 2007, 19：2470.
[29] Chico JM, Chini A, Fonseca S, Solano R. JAZ repressors set the rhythm in jasmonate signaling[J] . Current Opinion in Plant Biology, 2008, 3008, 11：486-494.
[30] Browse J. Jasmonate passes muster：a receptor and targets for the defense hormone[J] . Annual Review of Plant Biology, 2009, 60：183-205.
[31] Figueroa P. The Arabidopsis JAZ2 promoter contains a G-box and thymidine-rich module that are necessary and sufficient for jasmonate-dependent activation by MYC transcription factors and repression by JAZ proteins[J] . Plant and Cell Physiology, 2012, 53：330-343.
[32] Leon J. Role of plant peroxisomes in the production of jasmonic acid-based signals[J] . Subcell Biochem，（2013，69：299-313.
[33] Chung HS, Cooke TF, DePew CL, et al. Alternative splicing expands the repertoire of dominant JAZ repressors of jasmonate signaling[J] . Plant J, 2010, 63：613-622.
[34] Jiang S，Yao J，Ma KW，et al. Bacterial effector activates jasmonate signaling by directly targeting JAZ transcriptional repressors[J] . PLoS Pathog，2013，9：e1003715.
[35] Zhou W，Yao R，Li H，et al. New perspective on the stabilization and degradation of the F-box protein COI1 in Arabidopsis[J] . Plant Signal Behav，2013（8）. pii：e24973. doi：10. 4161/psb. 24973.
[36] Gimenez-Ibanez S，Boter M，Fernandez-Barbero G，et al. The bacterial effector HopX1 targets JAZ transcriptional repressors to activate jasmonate signaling and promote infection in Arabidopsis [J] . PLoS Biol，2014，12：e1001792.
[37] Sheard LB, Tan X, Mao H, et al. Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor[J] . Nature, 2010, 468：400-405.
[38] Mosblech A, Thurow C, Gatz C, et al. Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana [J] . Plant J, 2011, 65：949-957.
[39] Cheng Z, Sun L, Qi T, et al. The bHLH transcription factor MYC3 interacts with the jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis[J] . Molecular Plant, 2011, 4：279-288.
[40] Qi T，Huang H，Wu D，et al. Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy[J] . Plant Cell，2014，26：1118-1133.
[41] Traw MB, Bergelson J. Interactive effects of jasmonic acid, salicylic acid, and gibberellin on induction of trichomes in Arabidopsis[J] . Plant Physiology, 2003, 133：1367-1375.
[42] Wang W，Liu G，Niu H，et al. The F-box protein COI1 functions upstream of MYB305 to regulate primary carbohydrate metabolism in tobacco（Nicotiana tabacum L. cv. TN90）[J] . J Exp Bot，2014，65：2147-2160.
[43] Mandaokar A, Kumar VD, Amway M, Browse J. Microarray and differential display identify genes involved in jasmonate-dependent anther development[J] . Plant Mol Biol, 2003, 52：775-786.
[44] Wang KLC, Li H, Ecker JR. Ethylene biosynthesis and signaling networks[J] . The Plant Cell Online, 2002, 14：S131-S151.
[45] Guo H, Ecker JR. The ethylene signaling pathway：new insights[J] . Current Opinion in Plant Biology, 2004, 7（1）：40-49.
[46] Gao XH, Xiao SL, Yao QF, et al. An updated GA signaling ‘relief of repression’ regulatory model[J] . Molecular Plant, 2011, 4：601-606.
[47] Yang DL, Yao J, Mei CS, et al. Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade[J] . Proc Natl Acad Sci USA, 2012, 109：E1192-1200.
[48] Hou X，Ding L，Yu H . Crosstalk between GA and JA signaling mediates plant growth and defense[J] . Plant Cell Rep，2013，32：1067-1074.
[49] Acosta IF，Gasperini D，Chetelat A，et al. Role of NINJA in root jasmonate signaling[J] . Proc Natl Acad Sci USA，2013，110：15473-15478.
[50] Perez AC，Goossens A. Jasmonate signalling：a copycat of auxin signalling?[J] . Plant Cell Environ，2013，36：2071-2084.
[51] Moreno JE，Shyu C，Campos ML，et al. Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10[j] . Plant Physiol，2013，162：1006-1017.
[52] Zhu X，Zhu JK. Double repression in jasmonate-mediated plant defense[j] . Mol Cell，2013，50：459-460.
[53] Ballare CL. Light regulation of plant defense[J] . Annu Rev Plant Biol，2014，65：335-363.
[54] Sasaki-Sekimoto Y，Saito H，Masuda S，et al. Comprehensive analysis of protein interactions between JAZ proteins and bHLH transcription factors that negatively regulate jasmonate signaling[J] . Plant Signal Behav，2014，9（1）. pii：e27639. [Epub ahead of print] .
[55] Wasternack C. Perception，signaling and cross-talk of jasmonates and the seminal contributions of the Daoxin Xie's lab and the Chuanyou Li's lab[J] . Plant Cell Rep，2014，33：707-718.
[56] Rustioni L，Rocchi L，Guffanti E，et al Characterization of grape（Vitis vinifera L. ）berry sunburn symptoms by reflectance[J] . J Agric Food Chem，2014，[Epub ahead of print] .
[57] Ishiga Y，Ishiga T，Uppalapati SR，Mysore KS. Jasmonate ZIM-domain（JAZ）protein regulates host and nonhost pathogen-induced cell death in tomato and Nicotiana benthamiana[J] . PLoS One，2013，8：e75728.
[58] Toda Y，Tanaka M，Ogawa D，et al. RICE SALT SENSITIVE3 forms a ternary complex with JAZ and class-C bHLH factors and regulates jasmonate-induced gene expression and root cell elongation[J] . Plant Cell，2013，25：1709-1725.
[59] Toda Y，Yoshida M，Hattori T，Takeda S. RICE SALT SENSITIVE3 binding to bHLH and JAZ factors mediates control of cell wall plasticity in the root apex[J] . Plant Signal Behav，2013，8：e26256.
[60] Hakata M, Kuroda M, Ohsumi A, et al. Overexpression of a rice TIFY gene increases grain size through enhanced accumulation of carbohydrates in the stem[J] . Biosci Biotechnol Biochem, 2012, 76：2129-2134.
[61] Zhu D, Cai H, Luo X, et al. Over-expression of a novel JAZ family gene from Glycine soja, increases salt and alkali stress tolerance[J] .Biochemical and Biophysical Research Communications, 2012, 426（2）：273-279.
[62] Oh Y, Baldwin IT, Gális I. NaJAZh regulates a subset of defense responses against herbivores and spontaneous leaf necrosis in Nicotiana attenuata plants[J] .Plant Physiology, 2012, 159：769-788.
[63] Oh Y, Baldwin IT, Galis I. A jasmonate ZIM-domain protein NaJAZd regulates floral jasmonic acid levels and counteracts flower abscission in Nicotiana attenuata plants[J] . PloS One, 2013, 8：e57868.
[64] Dewey RE，Xie J. Molecular genetics of alkaloid biosynthesis in Nicotiana tabacum[J] . Phytochemistry，2013，94：10-27.
[65] Memelink J. Regulation of gene expression by jasmonate hormones[J] . Phytochemistry, 2009, 70：1560-1570.