fat-1 转基因动物研究进展

生物技术通报 ›› 2012, Vol. 0 ›› Issue (12): 8-12.

fat-1 转基因动物研究进展

杨慧婷^{1, 2}, 王洪梅¹, 方永志³, 刘文浩¹, 武建明¹, 何洪彬¹

1 山东省农业科学院奶牛研究中心，济南 250100 ；2 山东师范大学生命科学学院，济南 250014 ；3 济南军区军犬训练大队，济南 250100

收稿日期:2012-04-25 修回日期:2013-01-25 出版日期:2012-12-26 发布日期:2013-02-06
作者简介:杨慧婷, 女, 硕士研究生, 研究方向:细胞生物学;E-mail:hting.yang@yahoo.com.cn
基金资助:
: 国家奶牛产业技术体系建设专项，国家转基因重大专项（2009ZX08007-006B，2011ZX08007-002,2011ZX08008-004），山东省科技攻关课题（2009GG20002032），济南市高校院所自主创新计划项目（201004027）

Advances in fat-1 Transgenic Animals

Yang Huiting^1,2, Wang Hongmei¹, Fang Yongzhi³, Liu Wenhao¹, Wu Jianming¹, He Hongbin¹

1 Dairy Cattle Research Center，Shandong Academy of Agricultural Science，Jinan 250100 ；2 College of Life Science，Shandong NormalUniversity，Jinan 250014 ；3 Jinan Military Region Army Dog Training Group，Jinan 250010

Received:2012-04-25 Revised:2013-01-25 Published:2012-12-26 Online:2013-02-06

摘要/Abstract

摘要： 转染秀丽隐杆线虫fat-1 基因后的哺乳动物具备了将n-6 多不饱和脂肪酸（PUFAs）转化为n-3 PUFAs 的能力，可降低动物机体的n-6/n-3 PUFAs 比例。n-3 PUFAs 有益于人类健康，可减少多种相关疾病发生的风险，但人体内不能合成n-3 PUFAs，其必须依赖于富含n-3 PUFAs 的食品，fat-1 转基因动物将成为人类必需的n-3 PUFAs 的重要来源。对fat-1 及其转基因动物的研究现状进行综述。

关键词: fat-1, 基因, 转基因动物, n-3, 多不饱和脂肪酸

Abstract: Mammals engineered by fat-1 gene from Caenorhabditis elegans can convert n-6 polyunsaturated fatty acids（PUFAs）to n-3PUFAs，and decrease the ratio of n-6/n-3 PUFAs in vivo. Although n-3 polyunsaturated fatty acids have been shown to play an important role inhealth，and can reduce the risk of many diseases，humans can not synthesize the n-3 PUFAs automatically. This review summarized the statusof research about fat-1 gene and fat-1 transgenic animals.

Key words: fat-1 gene, Transgenic animal n-3, PUFAs

杨慧婷, 王洪梅, 方永志, 刘文浩, 武建明, 何洪彬. fat-1 转基因动物研究进展[J]. 生物技术通报, 2012, 0(12): 8-12.

Yang Huiting, Wang Hongmei, Fang Yongzhi, Liu Wenhao, Wu Jianming, He Hongbin. Advances in fat-1 Transgenic Animals[J]. Biotechnology Bulletin, 2012, 0(12): 8-12.

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