The Developments of Epigenetics and Epigenetics-based Modern Biomedicine and Pharmaceutics

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.005

Abstract

Abstract: Epigenetics and epigenetic mechanism-based biomedical technologies have emerged as important research fields in post-genomic area. In-depth investigation on epigenetic alterations of DNA methylation, histone modifications, non-coding RNAs, etc. in tumorigenesis, cardiovascular disease, diabetes, and neurodegenerative diseases associated with the elderly population is not only beneficial to the understanding of the molecular pathogenesis of the diseases, but also useful in exploring effective treatments based upon epigenetic mechanisms. This review first briefly introduces epigenetic modification mechanisms, then summarizes current research progress on abnormal epigenetic modifications in the disease conditions, and also discusses the relevant biomedical technology.

Key words: epigenetics, DNA methylation, histone post-translational modification, non-coding RNA, human diseases

Jiang Nan, Pan Xuefeng. The Developments of Epigenetics and Epigenetics-based Modern Biomedicine and Pharmaceutics[J]. Biotechnology Bulletin, 2015, 31(4): 105-119.

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