The Progress of Induced Pluripotent Stem Cells Research in China

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.006

Abstract

Abstract: The research on somatic cell reprogramming can trace back to 1930s when Hans Spemann firstly proposed the concept of embryos induction. 30 years later, John Gurdon successfully obtained cloned Xenopus laevis through somatic cell nuclear transfer（SCNT）. Finally in 1996, the first cloned sheep Dolly was created through SCNT. This achievement clearly demonstrated that the mammalian somatic cell fates can be reprogrammed to totipotent state by SCNT. However, SCNT technology faced with both ethics issues and therapeutic application challenges. It is until the year of 2006 when Yamanaka group built up the iPS（induced pluripotent stem cells, iPS cells）technology which can bypass the ethical problems. Subsequently, the iPS technology has become the most popular research topic in stem cell field. In this particular research field, the scientists in China has made great contributions especially in the optimization iPS technology, mechanism studies and the application of iPS technology in translational medical research. In this review, the major progresses made by our countries’ scientists in iPS field are summarized.

Key words: induced pluripotent stem cell, reprogramming, epigenetics reprogramming, mechanism, clinical application

Xu Kai, Chen Xia, Gao Shaorong. The Progress of Induced Pluripotent Stem Cells Research in China[J]. Biotechnology Bulletin, 2015, 31(4): 72-81.

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