Abstract: At nowadays in the promotion of precise medical treatment,how to achieve tumor targeted therapy and reduce the side-effects of radiotherapy is particularly critical after we understood the mechanism of the key molecular targets closely related to tumorigenesis. Aptamers are single-stranded DNA or RNA oligonucleotides which can bind with various targets at high affinity and specificity. Inorganic nanomaterial is an important part of nanomaterial as a medical diagnosis and treatment preparation. Taking the advantage of the properties of aptamers binding with their targets at high affinity,the system of their binding with inorganic nanomaterial can be applied in the tumor research in an integrated approach of targeted binding,biological imaging and drug delivery,concurrently which efficiently promotes the development of nucleic acid nanotechnology. In this review,we discuss the application of varied inorganic nanomaterial binding with the aptamers in tumor research and the safety of inorganic nanomaterial in medical applications,aiming at earlier achieving the development of new targeted therapy strategies to tumor.

Key words: aptamers, nanomaterial, tumor