Application of Metagenomics in Prevention and Control of Infectious Diseases

doi:10.13560/j.cnki.biotech.bull.1985.2017-0787

Abstract

Abstract: The outbreak of new infectious diseases poses a serious challenge to global public health prevention and control.Rapid identification of pathogens is the primary challenge in dealing with outbreaks emerging infectious diseases. It is difficult to detect unknown pathogens or pathogens with large mutations using traditional pathogen detection methods. Metagenomics based on high-throughput sequencing has shed light on the pathogen detection and identification. Nucleic acid extraction，high-throughput sequencing，data analysis and other key technologies continue to develop，making metagenomics become an important research direction for the prevention and control of new infectious diseases. Metagenomics can direct sequence many samples of the prevention and control of infectious diseases to obtain high-throughput sequencing data. It can combine the pathogenic nucleic acid database，through sequence alignment，mutation evolution analysis and other bioinformatics methods in to use. In this way，we can monitor the suspicious samples of the epidemic outbreak forecast and warning，identify pathogens and provide medication guidance，determine the phylogenetic relationship，trace the origin of the pathogen and investigate the epidemic. Ultimately，we can realize the target of rapid identification，typing，drug resistance and traceability analysis of the new outbreak of infectious diseases. As a new technology，metagenomics has great potential and development prospects in the field of prevention and control of infectious diseases. This article reviews the application of metagenomics in the pathogen detection，detection and traceability of infectious diseases in order to provide a new perspective for the prevention and control of infectious diseases.

Key words: metagenomics, prevention and control of infectious diseases, high throughput sequencing

LI Pei-han, LI Peng, SONG Hong-bin. Application of Metagenomics in Prevention and Control of Infectious Diseases[J]. Biotechnology Bulletin, 2018, 34(3): 43-52.

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