Transcriptome-metabolomics Analysis and Its Application in Studying Drug Action Mechanism

doi:10.13560/j.cnki.biotech.bull.1985.2018-0497

Abstract

Abstract: With the development of high-throughput sequencing technology,high-throughput integrated analysis technology is an essential means to obtain the final biological information,and it is a revolutionary change to the research method for traditional drug action mechanism. Transcriptomics,metabolomics and the use of their combination are important components of systems biology. In recent years,they have been widely used in various fields related to drug mechanism research,such as development of new drug,improvement of drug efficacy,evaluating drug toxicity,and guiding therapy by combined drugs,etc.,it has become an indispensable screening stage in studying the drug action mechanisms. Here we review transcriptomics,metabolomics and 4 transcriptome-metabolomics conjoint analysis methods,analyze the advantages and disadvantages of the different methods as well as the existing problems,and briefly describe the application of the combined analysis method in the study of the drug action mechanism in recent years. Concurrently,we forecast its next development and challenges,with a view to exploring the strategies of transcriptomics and metabolomics and their combination in studying drug action mechanisms for future drugs. We expect that this review may provide the reference for understanding the molecular mechanism of drug action and subsequently for exploring new research methods and approaches based on the existing research foundation.

Key words: transcriptomics, metabolomics, transcriptome-metabolism conjoint analysis method, drug action mechanism

JIN Yu, LI He-jian, FENG Cheng-qiang. Transcriptome-metabolomics Analysis and Its Application in Studying Drug Action Mechanism[J]. Biotechnology Bulletin, 2018, 34(12): 68-76.

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