Research Progress in the Quantitative and Unitive Detecting Technologies Based on Functional Nucleic Acid and Labeled Fluorescence

doi:10.13560/j.cnki.biotech.bull.1985.2018-0592

Abstract

Abstract: Functional nucleic acid is a natural or an artificial nucleic acid sequence with specific spatial conformation and biological function. It has advantages such as easy to be modified,low cost,high stability and strong specificity. After combined with fluorescence biosensors,the functional nucleic acid-based fluorescent biosensors have been widely used in the detection of environmental pollutants and risk factors of food as well as disease diagnosis. First,we clarify the concepts of functional nucleic acid and quantitative fluorescence detecting technology,and elaborates in detail the features of several key fluorescent materials,as well as their biological molecular recognition,the reaction principles and the luminous models with functional nucleic acid. Then,we describe,assess,and compare the quantitative and unitive detecting technologies based on functional nucleic acid and labeled fluorescence and their applications. Finally,we discuss the research significance and issues while applying the quantitative and unitive detecting technologies of functional nucleic acid and labeled fluorescence in varied detections and prospect the direction of future development and application.

Key words: functionalnucleic acid, fluorescence, luminous model, quantitative detection, biosensor

XIAO Bing, LUO Yun-bo, HUANG Kun-lun, ZHANG Yuan, XU Wen-tao. Research Progress in the Quantitative and Unitive Detecting Technologies Based on Functional Nucleic Acid and Labeled Fluorescence[J]. Biotechnology Bulletin, 2019, 35(7): 213-221.

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