Research Progress of miR-1246 in Diseases

doi:10.13560/j.cnki.biotech.bull.1985.2017.03.005

Abstract

Abstract: miRNAs are a class of small non-coding RNAs,involve in tissues metabolism,cells proliferation,differentiation,apoptosis and target genes expression,thus play an critical role in physiological and pathological processes. Nowadays,inventing effective miRNAs activators or inhibitors to treat and diagnose disease has become a new direction or entry point in the field of medical research. The newly discovered miR-1246 is regulated by P53,and is closely related to molecular mechanism of diseases. In this article,we summarize the miR-1246’s sequence structural features,molecular functional mechanism,review application potentials of miR-1246 in treating cancer,Ebola virus infection,and Down’s syndrome,and finally discuss its prospects,aiming at providing a theoretical reference for medical research.

Key words: miR-1246, cancer, Down's syndrome, Ebola virus infection, disease

HU Yu, WANG Ling, BI Wu, TAN Lin, XING Dan, ZUO Fu-yuan. Research Progress of miR-1246 in Diseases[J]. Biotechnology Bulletin, 2017, 33(3): 29-36.

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