Research Progress on the Nuclear Reprogramming After Somatic Cells Nuclear Transfer in Mammalian

doi:10.13560/j.cnki.biotech.bull.1985.2019-0168

Abstract

Abstract: Somatic cell nuclear transfer technology in mammalian has been developed for more than 20 years,however,the abnormal nuclear reprogramming during embryonic development is critical barrier to the application of this technology. At present,the key method to improve the efficiency of cloning is to overcome the error of reprogramming by adjusting the epigenetic modification in the reprogramming process,thereby improving the development efficiency of reconstructed embryos. Here,we summarize the abnormal of donor nuclear reprogramming in the development of early embryos after nuclear transfer,and discuss the research status in correcting these epigenetic modifications. Meanwhile,we prospect the possible reprogramming events and emerging technologies that influences the development of nuclear transfer embryos.

Key words: somatic cell nuclear transfer, reprogramming, epigenetic modification

WU Xiao, ZHUANG Zhan-wei, MA Xiao-li, HUANG Si-xiu, LI Zi-cong, XU Zheng. Research Progress on the Nuclear Reprogramming After Somatic Cells Nuclear Transfer in Mammalian[J]. Biotechnology Bulletin, 2019, 35(11): 187-194.

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