Biotechnology Bulletin ›› 2021, Vol. 37 ›› Issue (8): 263-274.doi: 10.13560/j.cnki.biotech.bull.1985.2020-1471

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Research Progress on Active Compounds Against Drug-resistant Microorganism from Plant Endophytes

WANG Nan(), SU Yu, LIU Wen-jie, FENG Ming, MAO Yu, ZHANG Xin-guo()   

  1. School of Life Science and Engineering,Lanzhou University of Technology,Key Laboratory of Screening and Deep Processing in New Tibetan Medicine of Gansu Province,Lanzhou 730050
  • Received:2020-12-02 Online:2021-08-26 Published:2021-09-10
  • Contact: ZHANG Xin-guo E-mail:1772708516@qq.com;biodrug@163.com

Abstract:

With the increase of bacterial resistance caused by irrational use of antibiotics year by year,bacterial resistance has become a serious problem all over the world. In order to solve this increasingly serious problem,searching new antimicrobial drugs is undoubtedly an important measure of solving this problem,in addition to the reasonable and standardized application of antibiotics. Plant endophytes are a new type of microbial resource that urgently needs to be developed,and its rich diversity of microbial classification and secondary metabolites provide the possibility of finding new active compounds against drug-resistant microorganism,showing great potential for research and development. In this paper,the recent research progress on active compounds against drug-resistant microorganism in endophytes is reviewed,aiming to provide a reference for the research of new drugs against drug-resistant microorganism.

Key words: plant endophytes, secondary metabolites, drug-resistance mechanism, active compounds against drug-resistant microorganism