Biotechnology Bulletin ›› 2014, Vol. 0 ›› Issue (4): 36-42.

• Review • Previous Articles     Next Articles

Studies on Diversity of Sponges-associated Fungi and Their Secondary Metabolites

Song Kai1,2,3, Hu Jie3, Lin Wenhan3, Ji Yubin1,2,3,   

  1. (1. Research Center on Life Sciences and Environmental Sciences,Harbin University o f Commerce,Harbin 150076;
    2. Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin 150076;
    3. State Key Laboratory of Natural and Biommietic Drugs,Peking University, Beijing 100191)
  • Received:2013-09-29 Online:2014-04-29 Published:2014-04-29

Abstract: Because of the unique physiological structure and digest system, marine sponges enrich large numbers of microorganisms. Lots of novel bioactive compounds were isolated and identified from sponges-associated fungi, which is highlight in marine drug discovery. The development on the distribution of fungi, the application of new technique, novel bioactive secondary metabolites and biological activities were reviewed.

Key words: Sponge, Symbiotic-fungi, Secondary metabolites, Chemical defense, Bioactivity