Research Progress on Drug Resistance of Staphylococcus aureus in Bovine Mastitis

doi:10.13560/j.cnki.biotech.bull.1985.2018-0317

Abstract

Abstract: Staphylococcus aureus is one of the most dominant pathogenic bacteria resulting in bovine mastitis. The role of antibiotics in the treatment of bovine mastitis is irreplaceable,however,antibiotics are dependent seriously or even over-spread,the drug resistance of S. aureus is becoming increasingly prominent,and it is particularly serious at the present stage in China. In recent years,the drug-resistant strains and profiles have widened gradually,and their drug resistance is increasing. The resistance mechanism becomes more and more complex,and the genes with drug resistance are varied. The widespread and multidrug-resistant of S. aureus from bovine mastitis is very serious,even the super drug-resistant bacteria,methicillin-resistant Staphylococcus Aureus（MRSA）,appeared,which brings great difficulties in the treatment of bovine mastitis. Severe drug resistance of S. aureus not only affects the dairy farming industry and the prevention and treatment of mastitis,also threatens human health directly or indirectly. Therefore,the key to solve the problem is to monitor S. aureus drug resistance and its migration as well as to identify its specific drug resistance mechanism. At present,S. aureus can produce drug resistance to antibacterial drugs such as β-lactams,aminoglycans,tetracyclines,macrolides,linamine and quinolones by different mechanisms,such as generating modification enzymes,changing the target of antibacterial drugs,reducing the permeability of cell wall and so on,but the mechanism of molecular drug resistance from gene coding remains unclear. A review here is made on the S. aureusdrug resistance and its molecular drug resistance mechanism in bovine mastitis,and the significance and problems of defining the mechanism of S. aureus drug resistance are discussed,aiming at providing ideas and basis for rationally applying drug and effective prevention and treatment of bovine mastitis in clinics.

Key words: mastitis：Staphylococcus aureus, antibacterial drug, drug resistance, molecular mechanism

ZHAO Yan-kun, LIU Hui-min, WANG Shuai, CAI Jian-xing, WANG Cheng, CHEN He. Research Progress on Drug Resistance of Staphylococcus aureus in Bovine Mastitis[J]. Biotechnology Bulletin, 2018, 34(10): 18-25.

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