Research Progress on the Secondary Metabolite of Purpureocillium lilacinum

doi:10.13560/j.cnki.biotech.bull.1985.2018-0049

Abstract

Abstract: Purpureocillium lilacinum is a filamentous fungus belonging to Purpureocillium of Ophiocordycipitaceae of Hypocreales of Ascomycota. It is a kind of broad-spectrum bio-control fungi,and it not only has good control effects on plant parasitic nematodes,aphids,red spiders,green house whitefly,leaf-cutting ants,etc.,but also has antagonistic effects on a variety of plant pathogenic fungi,bacteria and even viruses. P. lilacinum can secrete chitinase and serine proteases,thereby degrading the proteins and chitin constituents of the nematode epidermis,facilitating invasion and destruction of cellular components. P. lilacinum may also be endogenous to plants,producing effectors that antagonize other fungi. P. lilacinum may colonize the rhizosphere of plants,producing secondary metabolites that can inhibit fungi and nematodes. At present,the studies on the secondary metabolites of P. lilacinum mainly include the synthesis regulation,activity and molecular structure determination of non-ribosomal peptides,alkaloids,and polyketides. The non-ribosomal peptide compounds produced by P. lilacinum are leucinostatin A and B,alkaloid is paecilomide,and polyketide compounds are Acremoxanthone C and Acremonidin A. This paper mainly reviewed the research progress on the secondary metabolites from P. lilacinum,discussed research significance of secondary metabolites from P. lilacinum,and finally,prospected the study foreground of P. lilacinum,so as to provide a reference for the relevant researchers.

Key words: Purpureocillium lilacinum, secondary metabolite, leucinostatin, Acremoxanthone C, paecilomide

HAO Ze-ting, HAO Xiao-hui, YAN Jing, XIE Bing-yan, LIANG Li-qin. Research Progress on the Secondary Metabolite of Purpureocillium lilacinum[J]. Biotechnology Bulletin, 2018, 34(10): 11-17.

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