Research Advances in Hog1 MAPK Signaling Pathway in Fungi

doi:10.13560/j.cnki.biotech.bull.1985.2022-0335

Abstract

Abstract:

Mitogen-activated protein kinases（MAPK）pathways are common and well conserved in eukaryotic cells，and they are one of the very important signal transduction systems in living organisms. The extracellular stimulatory signal is transmitted to the intracellular MAPK signaling pathway through specific receptors on the cell membrane，this signaling pathway regulates cellular transcription levels and biochemical reactions by phosphorylating downstream transcription factors and regulating various enzymes，thereby enabling cells to adapt to changes in the external environment. The Hog1 MAPK signaling pathway was activated by stimuli such as extracellular hyperosmotic stress，and was essential for cell survival in a hyperosmotic environment. In recent years，an increasing number of studies have found that although this signaling pathway was highly conserved in eukaryotes，its composition varied from species to species. And the function of this signaling pathway was relatively diversified. This article reviews the composition and function of Hog1 MAPK signaling pathway and the cross-talk between this pathway and other pathways，aiming to provide a reference for further research on the mechanism of Hog1 MAPK signaling pathway and its cross-talk with other signaling pathways.

Key words: fungi, Hog1, MAPK, stress response

XU Ji-fen, CHEN Hong-fei, WANG Na, LIU Jing. Research Advances in Hog1 MAPK Signaling Pathway in Fungi[J]. Biotechnology Bulletin, 2022, 38(11): 32-40.

Figures/Tables 1

References 62

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