Research Progress in the Roles of DNA and Histone Methylations in Epigenetic Regulation

doi:10.13560/j.cnki.biotech.bull.1985.2021-1054

Abstract

Abstract:

In eukaryotes,as a common mechanism of epigenetic regulation,DNA and histone methylations mainly affect chromatin structure and gene transcription expression,especially in gene expression regulation of mammalian cells and maintaining genome stability. This paper reviews DNA methylation modification and its role in gene expression regulation,gene expression regulation mode,function and research progress of histone methylation modification,as well as the interaction between DNA and histone methylations in epigenetic regulation.

Key words: gene expression, epigenetic regulation, DNA methylation, histone methylation

ZHANG Miao, YANG Lu-lu, JIA Yan-long, WANG Tian-yun. Research Progress in the Roles of DNA and Histone Methylations in Epigenetic Regulation[J]. Biotechnology Bulletin, 2022, 38(7): 23-30.

Figures/Tables 2

References 63

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Lysine	H3 tail	H4 tail
K4	Set1,TRX,SET1A,SET1B,MLL1,MLL2,MLL3,MLL4,SMYD1,SMYD2,SMYD3,SET7/9,PRDM9	-
K9	Clr4,SU（VAR）3-9,G9a,SETDB1,ASH1,SUV39H1,SUV39H2,G9a,GLP,PRDM3,PRDM16	-
K27	EZH1,EZH2,G9A	-
K36	SET2,MES-4,SETD2,NSD1,NSD2,NSD3,SETD3,SMYD2,ASH1L,SETMAR,PRDM9	-
K79	DOT1L	-
K20	-	Set7,SET8,SET9,SUV4-20H1,SUV-20H2,SET9

Lysine	H3 tail	H4 tail
K4	Set1,TRX,SET1A,SET1B,MLL1,MLL2,MLL3,MLL4,SMYD1,SMYD2,SMYD3,SET7/9,PRDM9	-
K9	Clr4,SU（VAR）3-9,G9a,SETDB1,ASH1,SUV39H1,SUV39H2,G9a,GLP,PRDM3,PRDM16	-
K27	EZH1,EZH2,G9A	-
K36	SET2,MES-4,SETD2,NSD1,NSD2,NSD3,SETD3,SMYD2,ASH1L,SETMAR,PRDM9	-
K79	DOT1L	-
K20	-	Set7,SET8,SET9,SUV4-20H1,SUV-20H2,SET9