Biotechnology Bulletin ›› 2023, Vol. 39 ›› Issue (11): 137-149.doi: 10.13560/j.cnki.biotech.bull.1985.2023-0686

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Research Advances in the Enhancement of Microbial Tolerance to Acid Stress

HU Jin-chao(), SHEN Wen-qi, XU Chao-ye, FAN Ya-qi, LU Hao-yu, JIANG Wen-jie, LI Shi-long, JIN Hong-chen, LUO Jian-mei(), WANG Min   

  1. Key Laboratory of Industrial Fermentation Microbiology(Tianjin University of Science and Technology), Ministry of Education, Tianjin Key Lab of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457
  • Received:2023-07-15 Online:2023-11-26 Published:2023-12-20
  • Contact: LUO Jian-mei E-mail:15081112106@163.com;luojianmei@tust.edu.cn

Abstract:

Microorganisms are often exposed to accumulation of various acidic substances during the fermentation process, which can seriously inhibit fermentation activity and production performance of the strains. Therefore, microorganisms have formed complex response mechanisms for the adaptation of low pH stress by coordinating cellular multiple physiological systems, metabolic pathways and regulatory network during the long-term evolution. The acid tolerance enhancement of the industrial microorganisms is a key way to improve its production efficiency. This review summarizes the recent research advances in the improvement on cell resistance to acids by the adaptive laboratory evolution, pre-adaptation, genome shuffling, genetic engineering, the global transcription machinery engineering, system biology and synthetic biology. The challenges and outlook of the relevant research are also discussed.

Key words: microorganisms, acid stress, tolerance enhancement, strain modification, gene circuit