Research Progress on the Role of Transcription Factor HIF-1α and Its Signal Pathway in the Pathogenesis

doi:10.13560/j.cnki.biotech.bull.1985.2016.08.002

Abstract

Abstract:

Hypoxia inducible factor-1α（HIF-1α）is a transcription factor under hypoxia condition,which widely exists in mammals and human body. It is a key factor responding to hypoxic stress. HIF-1α is a subunit of hypoxia inducible factor-1（HIF-1）and considered as the master transcriptional regulator of cellular and developmental response to hypoxia,and regulates the activity of HIF-1. During hypoxia,HIF-1α translocates from the cytoplasm to the nucleus,where it dimerizes with HIF-1β and the transcriptionally active HIF-1 complex is formed;the activated HIF complex then associates with HREs in the regulatory regions of target genes to induce gene expression. Forming varied signal pathways with multiple proteins in up- and down- streams,HIF-1α mediates hypoxic signals,then regulates a series of hypoxic compensatory response of cell,which plays a crucial role in body growth,physiological and pathological processes,thus it is a focus of biomedical research. We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.

Key words: hypoxia inducible factor-1&#x003b1, signal pathway, disease

YANG Meng-si, ZHOU Na, WANG Zhi-gang,HAO Hui-fang. Research Progress on the Role of Transcription Factor HIF-1α and Its Signal Pathway in the Pathogenesis[J]. Biotechnology Bulletin, 2016, 32(8): 8-13.

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