Biotechnology Bulletin ›› 2019, Vol. 35 ›› Issue (1): 170-186.doi: 10.13560/j.cnki.biotech.bull.1985.2018-0524

Previous Articles     Next Articles

Research Progress on Fluorescent Copper Nanoparticles Mediated Biosensors

LIU Xing-yu1, LI Chun-hui1, TIAN Jing-jing1,2, SHAO Xiang-Li1,2, LUO Yun-bo1,2, XU Wen-tao1,2   

  1. 1. College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083;
    2. Beijing Advanced Innovation Center for Food Nutrition and Human Health,Key Laboratory of Safety Assessment of Genetically Modified Organism(Food Safety)in Ministry of Agriculture,China Agricultural University,Beijing 100083
  • Received:2018-06-07 Online:2019-01-26 Published:2019-01-23

Abstract: Fluorescent copper nanoparticles(CuNCs)are nanometer-sized copper crystals generated by using deoxyribonucleic acid(DNA)as a template and divalent copper ions(Cu2+)and ascorbic acid as reactants,and they are fluorescent and can be used to be output signal in biosensors. The generation of CuNCs is fast,simple,and safe. Therefore,many researches on the principles and applications of CuNCs have emerged in recent years. Here CuNCs mediated biosensors are classified in terms of mediators supporting the sensor operation and signal output mode. A detailed description of the principles of various sensors and comparison of the advantages and disadvantages of the biosensors are included,for the purpose of understanding the feasibility and versatility of(CuNCs)mediated biosensors after reading the development and directions of these biosensors. Finally,this review also discusses the shortcomings in applying the CuNCs biosensors and looks into its future development trend. This is aimed to inspire future research and development in this area and thus to develop copper nanoparticles mediated biosensors into more practical and convenient biosensing tool.

Key words: fluorescence, copper, nanocluster, biosensor, functional nucleic acid