Regulation of LKB1-AMPKα-SIRT1 Signal Pathway in Lipid Metabolism in the Adipose Tissue of Dairy Cows

doi:10.13560/j.cnki.biotech.bull.1985.2018-0707

Abstract

Abstract: The increasing volume and number of adipocyte leads to disorder of lipid metabolism in adipose tissue,which causes different chronic diseases such as type II diabetes,ketosis,fatty liver,and hyperlipidemia. The LKB1-AMPKα-SIRT1 signal pathway plays important regulating role in the lipid metabolism of dairy cows adipose tissue. AMPK as conservative serine/threonine kinase plays a pivotal role in the regulation of energy metabolism. LKB1（liver kinase B1）is a serine/threonine kinase,an upstream kinase of AMPKα,participates in various biological activities such as intracellular energy metabolism. Silencing information regulator factor 1（SIRT1）,a kind of NAD⁺-dependent histone deacetylase,can increase AMPKα activity by deactivating LKB1. This article reviews the regulation mechanisms of LKB1-AMPKα-SIRT1 signal transduction pathways in lipid metabolism of adipose tissue in dairy cows,aiming at providing a basis for further studying the regulating mechanisms of related signal pathways in the lipid metabolism of dairy cows.

Key words: LKB1, AMPKα, SIRT1, dairy cows, adipose tissue, lipid metabolism

MING Peng-fei, HUANG Ying-ying, DONG Yan-li, NIE Xing-can, FENG Shi-bin, WANG Xi-chun, CHENG Jian-bo, LI Jin-chun, WU Jin-jie, LI Yu. Regulation of LKB1-AMPKα-SIRT1 Signal Pathway in Lipid Metabolism in the Adipose Tissue of Dairy Cows[J]. Biotechnology Bulletin, 2019, 35(2): 176-181.

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