RNAi技术在抗甲型流感病毒中的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2014.12.009

摘要/Abstract

摘要： RNAi技术广泛应用于防治人类多种疾病病原的药物和疫苗开发中，并取得了巨大的成果。流感病毒极易发生抗原漂移和抗原转变，这给抗流感病毒药物和疫苗的研制提出很大的挑战。RNAi 技术的出现给流感的防治提供了新的思路。对近年来国内外利用 RNAi 技术开发抗流感病毒药物和新型流感疫苗研究现状及前景进行综述，以期为流感的综合防治研究提供参考。

关键词: 流感病毒, RNA, 干扰, siRNA, miRNA, 复制, 疫苗

Abstract: The RNAi technology has been widely used in drug and vaccine development of the prevention and treatment of various kinds of human diseases pathogeny,and has made great achievements.Antigenic drift and antigenic shift extremely easily occurred in influenza virus, which had put forward a bigchallenge for the development of anti-influenza virus drugs and vaccines.The appearance of RNAi technology gived good ideas for the prevention and control of influenza.This paper summarized the research status and prospects of using RNAi technology to develop anti-influenza virus drugs and new influenza vaccine at home and abroad in recent years, in order to provide references for the research for the prevention and control of influenza.

Key words: Influenza virus, RNA interference, siRNA, miRNA, Replication, Vaccine

韩庆功 ,郑玉姝. RNAi技术在抗甲型流感病毒中的研究进展[J]. 生物技术通报, 2014, 0(12): 55-60.

Han Qinggong, Zheng Yushu. Research Advance of RNAi in Anti-influenza Virus[J]. Biotechnology Bulletin, 2014, 0(12): 55-60.

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