半胱氨酸参与生物体重金属抗性的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017.05.004

摘要/Abstract

摘要： 半胱氨酸（Cys）是生物体硫酸盐同化途径的终产物,广泛存在于生物体内。生物体将氧化态硫吸收并还原后固定到半胱氨酸分子中,使其能够顺利参与生物体的其他代谢途径。因半胱氨酸结构中含有巯基,使得其能与重金属离子特异性结合,并直接或间接地参与生物体的重金属抗性。由于生物细胞是在异相条件下进行系列的、有序的生理生化过程,进一步研究Cys及其金属离子配合物在分子水平上的结构特征,对于在分子水平上研究Cys及其与金属离子的生理行为有重要的参考价值。近年来,新技术（如原子力显微镜）在生物科学方面的应用使得这一研究成为可能。对半胱氨酸的基本特性、生物合成途径及其参与生物体重金属抗性的研究进展进行了综述,旨为研究Cys在生物体重金属抗性过程中的解毒机制提供一定的科学理论依据。

关键词: 半胱氨酸, 生物合成途径, 重金属抗性

Abstract: Cysteine（Cys）,the final product of the sulfate assimilation pathway,widely exists in the organism. The oxidation state sulfur is absorbed and restored,and then integrated into the molecules skeletal structure of cysteine by organisms,participating in the other metabolic pathways of organisms. Because the structure of Cys contains thiol,which makes it being able to specifically bind with heavy metal ion,thus involving in the heavy metal resistance of organism,directly or indirectly. Considering a series of physiological and biochemical process in biological cells are orderly conducted under the heterogeneous condition,the investigation of Cys and the structure characteristics of Cys-M（M represents metal ion）complexes has significant reference value for studying Cys and the physiological behavior of Cys-M at the molecular level. In recent years,the application of new technique in the biological science,for example atomic force microscope（AFM）,makes this research feasible. In this paper,the basic characteristics and the biosynthetic pathway of Cys are introduced,concurrently,the research progress of Cys involved in heavy metal resistance are summarized,which aims to provide certain scientific theoretical basis for studying the detoxification mechanism of Cys in heavy metal resistance of organism.

Key words: cysteine, biosynthetic pathway, heavy metal resistance

张礼, 孙堆, 王晓, 郑春丽. 半胱氨酸参与生物体重金属抗性的研究进展[J]. 生物技术通报, 2017, 33(5): 26-33.

ZHANG Li, SUN Dui, WANG Xiao, ZHENG Chun-li. Research Progress on Cysteine Participation in Heavy Metal Resistance in Organism[J]. Biotechnology Bulletin, 2017, 33(5): 26-33.

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