钙网蛋白免疫调节的分子机制研究

生物技术通报 ›› 2013, Vol. 0 ›› Issue (3): 44-47.

钙网蛋白免疫调节的分子机制研究

吴薇,刘朝奇

三峡大学分子研究所，宜昌 443002

收稿日期:2012-09-17 修回日期:2013-03-21 出版日期:2013-03-20 发布日期:2013-03-21
作者简介:吴薇，女，硕士研究生，研究方向：肿瘤分子免疫学；E-mail ：lezhiweiwei@163.com

Mechanism of Immuno-regulation Activity of Calreticulin

Wu Wei, Liu Chaoqi

Institute of Molecular Biology, Three Gorges University, Yichang 443002）

Received:2012-09-17 Revised:2013-03-21 Published:2013-03-20 Online:2013-03-21

摘要/Abstract

摘要： 钙网蛋白(Calreticulin，CRT) 是46 kD 大小的Ca2+ 结合内质网常驻蛋白，具有调节细胞内钙浓度、增强抗原递呈及抑制血管生成等多种生物学功能。从机体凋亡细胞的清除、抗原提呈、信号转导及与体液免疫多方面阐述近来钙网蛋白在机体免疫调节分子机制的最新进展，以期为钙网蛋白的致病机制及免疫干预奠定理论和试验基础。

关键词: 钙网蛋白, 免疫调节, 分子机制, 抗原提呈

Abstract: Calreticulin (CRT) is a 46 kD Ca2+-binding resident protein which regulates cellular Ca2+ concentration and enhances angtigen presentation and inhibits angiogenesis. The review has shown that calreticulin is involved in molecular mechanism of immuno-regulation activity of calreticulin by clearance of apoptotic cells and angtigen presentation and signal transduction and humoral immunity and is expected to provide theory and experiment foundation for the pathogenic mechanisms and immune interventions of CRT.

Key words: Calreticulin, Immuno-regulation, Molecular mechanism, Angtigen presentation

吴薇,刘朝奇. 钙网蛋白免疫调节的分子机制研究[J]. 生物技术通报, 2013, 0(3): 44-47.

Wu Wei, Liu Chaoqi. Mechanism of Immuno-regulation Activity of Calreticulin[J]. Biotechnology Bulletin, 2013, 0(3): 44-47.

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