LncRNA在哺乳动物毛囊发育调控中的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2019-0187

摘要/Abstract

摘要： 长链非编码RNA（long non-coding RNA,lncRNA）是一类长度超过200 nt,本身不具编码能力的真核转录本,是基因编码蛋白的关键调节器,在转录水平和转录后水平调节基因的表达,广泛分布于动植物基因组中,作为一类重要的调节因子参与生命发育周期、细胞分化及疾病相关的一些生物学过程。目前,已有一些与皮肤生物学相关lncRNA的报道,但其在皮肤毛囊发育和毛发纤维中的功能及作用机制鲜有报道。近年来,新一代测序技术和芯片技术的结合为lncRNA的鉴定提供了更加有效和快速的途径。研究表明,部分lncRNA对皮肤毛囊细胞的增殖、分化及真皮乳头的形成具有一定影响,其相关靶基因参与调控毛囊的周期性生长。结合近期研究进展就lncRNA对毛囊生长发育的调控作用进行了综述,旨在为后续研究哺乳动物毛囊生长发育相关lncRNA的作用及调控机制奠定理论基础。

关键词: lncRNA, 皮肤, 毛囊, 调控机制

Abstract: Long non-coding RNA is a kind of eukaryotic transcripts that are more than 200nt in length and do not encode proteins by themselves. It is a key regulator of protein-coding gene expression,which is widely distributed in the genome of animals and plants,regulating gene expression at the transcriptional and post-transcriptional levels,and as an important regulator participates biological processes in life development cycles,cell differentiation and diseases. Although,several lncRNAs relevant to skin biology have been reported,the detailed functions and mechanisms of lncRNAs in hair follicle development and hair fibers are rare. The combination of new generation sequencing technology and microarray technology provides more accurate and rapid way for the identification of lncRNAs. It has been showed that some lncRNAs affect the cells proliferation and differentiation of skin hair follicle and the formation of dermal papilla,and their target genes involve in the regulation of in the periodic growth of hair follicles. In this review,the regulatory effect of lncRNA on hair follicle growth and development is summarized in order to provide a theoretical basis for the further study of the role and regulatory mechanism of lncRNA related to mammalian hair follicle growth and development.

Key words: lncRNA, skin, hair follicle, regulatory mechanism

常永芳, 包鹏甲, 褚敏, 吴晓云, 梁春年, 阎萍. LncRNA在哺乳动物毛囊发育调控中的研究进展[J]. 生物技术通报, 2019, 35(8): 205-212.

CHANG Yong-fang, BAO Peng-jia, CHU Min, WU Xiao-yun, LIANG Chun-nian, YAN Ping. Research Progress on the Regulation of LncRNA in the Development of Mammalian Hair Follicle[J]. Biotechnology Bulletin, 2019, 35(8): 205-212.

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