高产氨基葡萄糖基因工程菌的研究进展

摘要/Abstract

摘要： 氨基葡萄糖(GlcN)又称氨基葡糖或葡糖胺，是葡萄糖的一个羟基被氨基取代后的化合物，在医药和保健领域具有广泛应用。氨基葡萄糖的传统生产方法主要采取酸解几丁质法，受原料限制产量低，污染比较严重，构建高效产氨基葡萄糖的基因工程菌可以避免这些问题。介绍了氨基葡萄糖的代谢途径，以及最近几年国内外产氨基葡萄糖基因工程菌的构建和氨基葡萄糖的发酵培养，对氨基葡萄糖和乙酰氨基葡萄糖的发酵生产有重大的指导意义。

关键词: 氨基葡萄糖, 乙酰氨基葡萄糖, 基因工程菌, 发酵

Abstract: Glucosamine(GlcN), also called amino sugar, was a compound derived from the substitution of a hydroxyl group of glucose molecule with an amino group. GlcN found a wide-range of applications in health food and pharmaceutical industries. Glucosamine was currently produced by extraction and acid hydrolysis of chitin from shellfish waste, which was limited by the amount of raw material available and existed great risks of environment pollution. However, recombinant strain of gene engineering to overexpress the glucosamine could avoid those problems. the gene engineering strain, its metabolic pathway and fermentation of glucosamine were introduced. It is a great significance to ferment glucosamine and N-acetyglucosamine.

Key words: Glucosamine, N-acetyglucosamine, Gene engineering strain, Fementation

刘佃磊, 李丕武, 李瑞瑞, 王升, 王瑞明. 高产氨基葡萄糖基因工程菌的研究进展[J]. 生物技术通报, 2014, 0(3): 36-41.

Liu Dianlei, Li Piwu, Li Ruirui, Wang Sheng, Wang Ruiming. Research Advance of the Construction of Gene Engineering Strains for Glucosamine[J]. Biotechnology Bulletin, 2014, 0(3): 36-41.

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