[1] Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways[J]. Nature, 2015, 517(7534):302-310. [2] Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1:from lysosomes to disease[J]. Trends Mol Med, 2012, 18(9):524-533. [3] Xu J, Wang Y, Tan X, et al. MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis[J]. Autophagy, 2012, 8(6):873-882. [4] Levine B, Ranganathan R. Autophagy:Snapshot of the network[J]. Nature, 2010, 466(7302):38-40. [5] Rabinowitz JD, White E. Autophagy and Metabolism[J]. Science, 2010, 330(6009):1344-1348. [6] Lynch CJ. Role of leucine in the regulation of mTOR by amino acids:revelations from structure-activity studies[J]. J Nutr, 2001, 131(3):861S-865S. [7] Mordier S, Deval C, Béchet D, et al. Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C 2 C 12 myotubes through a mammalian target of rapamycin independent signaling pathway[J]. J Biol Chem, 2000, 275(38):29900-29906. [8] Yan X, Sun Q, Ji J, et al. Reconstitution of leucine-mediated autop-hagy via the mTORC1-Barkor pathway in vitro[J]. Autophagy, 2012, 8(2):213-221. [9] Sheen JH, Zoncu R, Kim D, et al. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo[J]. Cancer Cell, 2011, 19(5):613-628. [10] Angcajas AB, Hirai N, Kaneshiro K, et al. Diversity of amino acid signaling pathways on autophagy regulation:a novel pathway for arginine[J]. Biochem Biophys Res Commun, 2014, 446(1):8-14. [11] Changou CA, Chen YR, Xing L, et al. Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy[J]. PNAS, 2014, 111(39):14147-14152. [12] Kung HJ, Changou CA, Li CF, et al. Chromatophagy:autophagy goes nuclear and captures broken chromatin during arginine-starvation[J]. Autophagy, 2015, 11(2):419-421. [13] Xu L, Kanasaki M, He J, et al. Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules[J]. Biochim Biophys Acta, 2013, 1832(10):1605-1612. [14] Laxman S, Sutter BM, Tu BP. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A[J]. Autophagy, 2014, 10(2):386-387. [15] van der Vos KE, Coffer PJ. Glutamine metabolism links growth factor signaling to the regulation of autophagy[J]. Autophagy, 2012, 8(12):1862-1864. [16] Cheong H, Lindsten T, Wu J, et al. Ammonia-induced autophagy is independent of ULK1ULK2 kinases[J]. PNAS, 2011, 108(27):11121-11126. [17] Hu ZY, Li SL, Cao ZJ. Glutamine increases autophagy of liver cells in weaned calves[J]. J Dairy Sci, 2012, 95(12):7336-7339. [18] Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy[J]. Cell, 2009, 136(3):521-534. [19] Chen R, Zou Y, Mao D, et al. The general amino acid control pathway regulates mTOR and autophagy during serumglutamine starvation[J]. J Cell Biol, 2014, 206(2):173-182 . [20] Lin TC, Chen YR, Kensicki E, et al. Autophagy:resetting glutamine-dependent metabolism and oxygen consumption[J]. Autophagy, 2012, 8(10):1477-1493. [21] Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism[J]. Cell, 2006, 124(3):471-484. [22] Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling[J]. Cell Research, 2014, 24(1):42-57. [23] Mortimore GE, Schworer CM. Induction of autophagy by amino-acid deprivation in perfused rat liver[J]. Nature, 1977, 270(5633):174-176. [24] Wauson EM, Zaganjor E, Lee AY, et al. The G protein-coupled taste receptor T1R1T1R3 regulates mTORC1 and autophagy[J]. Mol Cell, 2012, 47(6):851-862. [25] Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery[J]. Mol Biol Cell, 2009, 20(7):1992-2003. [26] Ghislat G, Patron M, Rizzuto R, et al. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca 2+ calmodulin-dependent kinase kinase-β CaMKK[J]. J Biol Chem, 2012, 287(46):38625-38636. [27] Kim M, Fekadu J, Maronde E, et al. Alleviation of autophagy by knockdown of Beclin-1 enhances susceptibility of hippocampal neurons to proapoptotic signals induced by amino acid starvation[J]. Histochem Cell Biol, 2013, 139(1):99-108. [28] Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms[J]. Proc Natl Acad Sci USA, 2003, 100(17):9779-9784. [29] Gibbings D, Mostowy S, Voinnet O. Autophagy selectively regulates miRNA homeostasis[J]. Autophagy, 2013, 9(5):781-783. [30] Wu H, Wang F, Hu S, et al. MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C 2 C 12 myoblasts[J]. Cell Signal, 2012, 24(11):2179-2186. [31] Korkmaz G, Tekirdag KA, Ozturk DG, et al. MIR376A is a regulator of starvation-induced autophagy[J]. PLoS One, 2013, 8(12):e82556. [32] Korkmaz G, le Sage C, Tekirdag KA, et al. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1[J]. Autophagy, 2012, 8(2):165-176. [33] Dubinsky AN, Dastidar SG, Hsu CL, et al. Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy[J]. Cell Metab, 2014, 20(4):626-638. [34] Ye P, Liu Y, Chen C, et al. An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation[J]. Mol Cell, 2015, 57(4):708-720. [35] Tekirdag KA, Korkmaz G, Ozturk DG, et al. MIR181a regulates starvation- and rapamycin- induced autophagy through targetingof atg5[J]. Autophagy, 2013, 9(3):374-385. |