[1] |
López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging[J]. Cell, 2013, 153(6):1194-1217.
doi: 10.1016/j.cell.2013.05.039
pmid: 23746838
|
[2] |
Zhang X, Yang Y, Su J, et al. Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats[J]. Geroscience, 2021, 43(2):709-725.
doi: 10.1007/s11357-020-00188-y
URL
|
[3] |
Barzilai N, Huffman DM, Muzumdar RH, et al. The critical role of metabolic pathways in aging[J]. Diabetes, 2012, 61(6):1315-1322.
doi: 10.2337/db11-1300
pmid: 22618766
|
[4] |
Pellanda P, Ghosh TS, O’Toole PW. Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions[J]. Curr Opin Biotechnol, 2020, 70:48-55.
doi: 10.1016/j.copbio.2020.11.001
URL
|
[5] |
Psychogios N, Hau DD, Peng J, et al. The human serum metabolome[J]. PLoS One, 2011, 6(2):e16957.
doi: 10.1371/journal.pone.0016957
URL
|
[6] |
Copes N, Edwards C, Chaput D, et al. Metabolome and proteome changes with aging in Caenorhabditis elegans[J]. Exp Gerontol, 2015, 72:67-84.
doi: 10.1016/j.exger.2015.09.013
pmid: 26390854
|
[7] |
Cheng SS, Larson MG, McCabe EL, et al. Distinct metabolomic signatures are associated with longevity in humans[J]. Nat Commun, 2015, 6(1):1-10.
|
[8] |
Zheng X, Chen T, Zhao A, et al. The brain metabolome of male rats across the lifespan[J]. Sci Rep, 2016, 6:24125.
doi: 10.1038/srep24125
URL
|
[9] |
Bouatra S, Aziat F, Mandal R, et al. The human urine metabolome[J]. PLoS One, 2013, 8(9):e73076.
doi: 10.1371/journal.pone.0073076
URL
|
[10] |
Wang X, Zeng C, Lin J, et al. Metabonomics approach to assessing the modulatory effects of St John’s wort, ginsenosides, and clomipramine in experimental depression[J]. J Proteome Res, 2012, 11(12):6223-6230.
doi: 10.1021/pr300891v
URL
|
[11] |
Wu G. Amino acids:metabolism, functions, and nutrition[J]. Amino Acids, 2009, 37(1):1-17.
|
[12] |
Stockler S, Plecko B, Gospe SM Jr, et al. Pyridoxine dependent epilepsy and antiquitin deficiency:Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up[J]. Mol Genet Metab, 2011, 104(1/2):48-60.
doi: 10.1016/j.ymgme.2011.05.014
URL
|
[13] |
Sperringer JE, Addington A, Hutson SM. Branched-chain amino acids and brain metabolism[J]. Neurochem Res, 2017, 42(6):1697-1709.
doi: 10.1007/s11064-017-2261-5
pmid: 28417264
|
[14] |
de Koning TJ, Snell K, Duran M, et al. L-serine in disease and development[J]. Biochem J, 2003, 371(Pt 3):653-661.
pmid: 12534373
|
[15] |
Zhang D, Chia C, Jiao X, et al. D-mannose induces regulatory T cells and suppresses immunopathology[J]. Nat Med, 2017, 23(9):1036-1045.
doi: 10.1038/nm.4375
URL
|
[16] |
Onkenhout W, Groener JE, Verhoeven NM, et al. L-Arabinosuria:a new defect in human pentose metabolism[J]. Mol Genet Metab, 2002, 77(1/2):80-85.
doi: 10.1016/S1096-7192(02)00125-7
URL
|
[17] |
Li M, Wang X, Aa J, et al. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy[J]. Am J Physiol Renal Physiol, 2013, 304(11):F1317-F1324.
doi: 10.1152/ajprenal.00536.2012
URL
|
[18] |
Shibata K. Urinary excretion of 2-oxo acids is greater in rats with streptozotocin-induced diabetes[J]. J Nutr Sci Vitaminol, 2018, 64(4):292-295.
doi: 10.3177/jnsv.64.292
URL
|
[19] |
Orlandi I, Alberghina L, Vai M. Nicotinamide, nicotinamide riboside and nicotinic acid—emerging roles in replicative and chronological aging in yeast[J]. Biomolecules, 2020, 10(4):604.
doi: 10.3390/biom10040604
URL
|
[20] |
Özçelik S, Öztekin N, Kıykım E, et al. Capillary electrophoresis with capacitively coupled contactless conductivity detection for the determination of urinary ethylmalonic acid for the diagnosis of ethylmalonic aciduria[J]. J Sep Sci, 2020, 43(7):1365-1371.
doi: 10.1002/jssc.201901044
pmid: 31958360
|
[21] |
Drousiotou A, DiMeo I, Mineri R, et al. Ethylmalonic encephalopathy:application of improved biochemical and molecular diagnostic approaches[J]. Clin Genet, 2011, 79(4):385-390.
doi: 10.1111/j.1399-0004.2010.01457.x
pmid: 20528888
|
[22] |
Loots DT. Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia[J]. J Inherit Metab Dis, 2009, 32(3):403-411.
doi: 10.1007/s10545-009-1071-6
pmid: 19343532
|
[23] |
Destanoğlu O, Zeydanlı D, Cansever MŞ, et al. Ion chromatographic method for the determination of orotic acid in urine[J]. Anal Biochem, 2018, 563:9-14.
doi: S0003-2697(18)30546-3
pmid: 30267708
|
[24] |
Wang Q, Wen X, Kong J. Recent progress on uric acid detection:a review[J]. Crit Rev Anal Chem, 2020, 50(4):359-375.
doi: 10.1080/10408347.2019.1637711
URL
|
[25] |
Ames BN, Cathcart R, Schwiers E, et al. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer:a hypojournal[J]. PNAS, 1981, 78(11):6858-6862.
doi: 10.1073/pnas.78.11.6858
pmid: 6947260
|
[26] |
Bae SJ, Lee JS, Lee EK, et al. The anti-apoptotic action of 5-hydroxyindole:protection of mitochondrial integrity[J]. Biol Pharm Bull, 2010, 33(4):550-555.
doi: 10.1248/bpb.33.550
URL
|