Porcine Pluripotent Stem Cells:Facts, Challenges and Hopes

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.009

Abstract

Abstract: Pluripotent stem cells, including embryonic stem cells, embryonic germ cells and induced pluripotent stem cells, have the ability to differentiate into a variety of specific cell lines. Swine is considered as a kind of ideal model for pre-clinical development of human xenotransplantation, therapeutic approaches and regenerative medicine due to its morphological and functional affinity with man. However, a number of open questions need to be addressed since we know little about the sorting, derivation, characterization and mechanisms of porcine pluripotent stem cells. In this review, we elaborated the latest progresses on the derivation of porcine pluripotent stem cells, the evaluation criteria of stemness, scientific and technique questions encountere, and we also provide our perspectives on the future study ofporcine pluripotentstem cells research, in the hope of sharing experimence of exploring this field with other researchers.

Key words: swine, pluripotent stem cells, embryonic stem cells, induced pluripotent stem cells, embryonic germ cells

Xue Binghua, Liu Zhonghua. Porcine Pluripotent Stem Cells:Facts, Challenges and Hopes[J]. Biotechnology Bulletin, 2015, 31(4): 82-91.

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