The Safety Assessment of Genetically Modified Agro-Products

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.010

Abstract

Abstract: Transgenic biotechnology has become the main solution to food shortage, agricultural environmental pollution, improving of food nutrition and processing properties, with the rapid development of transgenic biotechnology. With the commercialization of transgenic crops is continuously promoted, the species and amounts of genetically modified（GM）agro-products have rapidly increased. However, there have been public concerns about the safety of GM agro-products. In this paper, the necessity of safety assessment of GM agro-products, and the research progresses of food safety assessment, food processing safety assessment and feed safety assessment are reviewed. Also, the key issues of transgenic food safety evaluation, including food safety assessment of new types of transgenic agro-products and safety standardization of GM agro-products, are discussed from different perspectives. It would make the public scientifically understand safety of GM agro-products, and provide scientific basis and support for the foundation of criterion system for safety assessment of GM agro-products.

Key words: genetically modified agro-products, safety assessment, food safety, food processing safety, feed safety

Xing Fuguo, Hua Huijuan, Liu Yang. The Safety Assessment of Genetically Modified Agro-Products[J]. Biotechnology Bulletin, 2015, 31(4): 17-24.

References

[1] 董宏. 当今转基因食品的问题［J］. 生物技术, 2013, 10：13.
[2] 宋欢, 王坤立, 许文涛, 等. 转基因食品安全性评价研究进展［J］. 食品科学, 2014, 35（15）：295-303.
[3] 王中凤. 转基因食品相对安全性分析［J］. 中国食品工业, 2007, 1：43-44.
[4] 魏益民. 食品安全学导论［M］. 北京：科学出版社, 2009.
[5] 左娇, 郭运玲, 孔华, 等. 转基因玉米安全性评价研究进展［J］. 玉米科学, 2014, 22（1）：73-78.
[6] 曹正辉, 王占彬, 顾宪红, 等. 转基因水稻饲用安全性评价的研究进展［J］. 动物营养与饲料科学, 2013, 40（11）：88-92.
[7] 王铭. 转基因大豆的安全性研究现状［J］. 黑龙江气象, 2014, 31（3）：26-27.
[8] 王南. 转基因食品安全性分析［J］. 园艺与种苗, 2014（7）：51-53.
[9] Jiao Z, Si XX, Li GK, et al. Unintended compositional changes in transgenic rice seeds（Oryza sativa L.）studied by spectral and chromatographic analysis coupled with chemometrics methods［J］. Journal of Agricultural and Food Chemistry, 2010, 58（3）：1746-1754.
[10] Zhou X, Dong Y, Xiao X, et al. A- 90 day toxicology study of high-amylose transgenic rice grain in Sprague Dawley rats［J］. Food and Chemical Toxicology, 2011, 49（12）：3112-3118.
[11] 郭明璋, 许文涛, 罗云波, 等. 中国食物过敏原数据库的建立与应用［J］. 食品安全质量检测学报, 2014, 9（5）：2948-2952.
[12] FAO/WHO. Evaluation of allergenicity of genetically modified foods［R］. Rome：FAO, 2001.
[13] 孙拿拿, 张馨, 崔文明, 等. 食品致敏性评价啮齿类动物模型研究-C3H/HeJ小鼠动物模型［J］. 卫生研究, 2010, 39（3）：310- 312.
[14] Xu DJ, Ning L, Yong NW, et al. Studies on BN rats model to determine the potential allergenicity of proteins from genetically modified foods［J］. World Journal of Gastroenterology, 2005, 11（34）：5381-5384.
[15] Cao S, He X, Xu W, et al. Potential allergenicity research of Cry1C protein from genetically modified rice［J］. Regulatory Toxicology and Pharmacology, 2012, 63（2）：181-187.
[16] Dearman RJ, Kimber I. Determination of protein allergenicity：studies in mice［J］. Toxicology Letters, 2001, 120：181-186.
[17] 向钱, 贾旭东, 王伟, 等. BN大鼠致敏动物模型研究［J］. 中国食品卫生杂志, 2008, 20（5）：393-396.
[18] 陈飞, 刘阳, 邢福国. 转基因食品的免疫安全性评价［J］. 食品科学, 2012, 33（9）：296-300.
[19] Hammond B, Duder R, Lemen J, et al. Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn［J］. Food and Chemical Toxicology, 2004, 42：1003-1014.
[20] Hammond B, Lemen J, Duder R, et al. Results of 90-day safety assurance study with rats fed grain from corn rootworm-protected com［J］. Food and Chemical Toxicology, 2006, 44：147-160.
[21] 邢福国, 刘阳, 秦海峰, 等. 转Cry1Ac/Sck基因大米的免疫毒理学评价［J］. 核农学报, 2012, 26（6）：906-910.
[22] Zhou C, Wang J, et al. Allergenicity assessment of a genetically modifiled protein recombinant human lactoferrin［J］. Allergy Therapy, 2013（13）：1-6.
[23] Teshima R, Watanabe T, Okunuki H, et al. Effect of subchronic feeding of genetically modified corn（CBH351）on immune system in BN rats and B10A mice［J］. Journal of the Food Hygienic Society of Japan, 2002, 43：273-279.
[24] 张焕春, 陈笑芸, 汪小福, 等. 转基因作物的非预期效应及其检测［J］. 浙江农业学报, 2012, 24（1）：125-132.
[25] 赵艳, 李燕燕. 组学技术评价转基因农作物的非预期效应［J］. 遗传, 2013, 35（12）：1360-1367.
[26] Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays［J］. Nature, 2000, 405（6788）：827-836.
[27] Cheng KC, Beaulieu J, Iquira E, et al. Effect of transgenes on global gene expression in soybean is within the natural range of variation of conventional cultivars［J］. Food Chemistry, 2008, 56（9）：3057-3067.
[28] Coll A, Nadal A, Collado R, et al. Natural variation explains most transcriptomic changes among maize plants of MON810 and comparable non-GM varieties subjected to two N-fertilization farming practices［J］. Plant Molecular Biology, 2010, 73（3）：349-362.
[29] Coll A, Nadal A, Rossignol M, et al. Proteomic analysis of MON810 and comparable non-GM maize varieties grown in agricultural fields［J］. Transgenic Research, 2011, 20（4）：939-949.
[30] Wang Y, Xu WT, Zhao WW, et al. Comparative analysis of the proteomic and nutritional composition of transgenic rice seeds with Cry1ab/ac genes and their non-transgenic counterparts［J］. Cereal Science, 2012, 55（2）：226-233.
[31] Xue K, Yang J, Liu B, et al. The integrated risk assessment of transgenic rice Oryza sativa：A comparative proteomics approach［J］. Food Chemistry, 2012, 135（1）：314-318.
[32] Kim JK, Park SY, Lee SM, et al. Unintended polar metabolite profiling of carotenoid-biofortified transgenic rice reveals substantial equivalence to its non-transgenic counterpart［J］. Plant Biotechnology Reports, 2013, 7（1）：121-128.
[33] Zhou J, Zhang L, Li X, et al. Metabolic profiling of transgenic rice progeny using gas chromatography-mass spectrometry：the effects of gene insertion, tissue culture and breeding［J］. Metabolomics, 2012, 8（4）：529-539.
[34] Chang YW, Zhao CX, Zhu Z, et al. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes［J］. Plant Molecular Biology, 2012, 78（45）：477-487.
[35] Gryson N. Effect of food processing on plant DNA degradation and PCR-based GMO analysis：a review［J］. Analytical and Bioanalytical Chemistry, 2010, 396（6）：2003-2022.
[36] 王林, 韩飞, 李爱科, 等. 不同加工工艺对大豆转基因成分及调控元件的影响［J］. 大豆科学, 2011, 30（1）：136-140.
[37] 王林, 韩飞, 李爱科, 等. 粉碎和膨化工艺对大豆转基因成分及调控元件的影响［J］. 粮油食品科技, 2011, 19（2）：9-11.
[38] 王林, 韩飞, 李爱科, 等. 干热加工工艺对大豆转基因成分及调控元件的影响［J］. 食品科学, 2011, 32（13）：229-233.
[39] Ballari RV, Martin A. Assessment of DNA degradation induced by thermal and UV radiation processing：Implications for quantification of genetically modified organisms［J］. Food Chemistry, 2013, 141（3）：2130-2136.
[40] Fernandes TJ, Oliveira M, Mafra I. Tracing transgenic maize as affected by bread making process and raw material for the production of a traditional maize bread, broa［J］. Food Chemistry, 2013, 138（1）：687-692.
[41] Zhang W, Xing F, Selvaraj JN, et al. Comparison of DNA extraction methods for GM rice and GM rice-derived food products［J］. Journal of Food Biochemistry, 2014, 38：388-396.
[42] Zhang W, Xing F, Selvaraj JN, et al. Degradation of endogenous and exogenous genes of genetically modified rice with Cry1Ab during food processing［J］. Journal of Food Science, 2014, 79（5）：T1055-T1065.
[43] Xing F, Zhang W, Selvaraj JN, et al. DNA degradation in genetically modified rice with Cry1Ab by food processing methods：Implications for the quantification of genetically modified organisms［J］. Food Chemistry, 2015, 174：132-138.
[44] 秦海峰, 刘阳, 邢福国. 转Cry1Ac/sck基因糙米作为肉仔鸡日粮原料的营养安全性［J］. 华北农学报, 2011, 26（5）：135-140.
[45] 秦海峰, 刘阳, 邢福国, 等. 转Cry1Ac/Sck基因糙米作为肉仔鸡日粮原料对肠道菌群的影响研究［J］. 中国农学通报, 2012, 28（14）：27-31.
[46] 徐志远, 刘阳, 邢福国, 等. 转Cry1Ac/sck 基因糙米作鲤鱼日粮原料营养学评价［J］. 粮食与饲料工业, 2011, （7）：57-60.
[47] Obembe OO, Popoola JO, Leelavathi S, et al. Advances in plant molecular framing［J］. Biotechnology Advances, 2011, 29（2）：210-222.
[48] Chatorvedi P, Chowdhary A. Plant derived vaccine：a review［J/OL］. （2014-02-22）［2014-03-27］. http：//www. grin. com/en/e-book/269489/plant-derived-vaccine.
[49] 梅晓宏, 许文涛, 贺晓云, 等. 新型转基因植物及其食用安全性评价对策研究进展［J］. 食品科学, 2013, 34（5）：308-312.
[50] 沈平, 黄昆仑, 厉建萌, 等. 国际转基因生物食用安全检测及其标准化［M］. 北京：中国农业大学&农业部科技发展中心, 2010：20-46.