Research Advances on Long Non-coding RNA

doi:10.13560/j.cnki.biotech.bull.1985.2016.09.004

Abstract

Abstract: The completion of the Human Genome Project confirmed that there is a total of 30-35 thousand coding genes,the encoding information of these genes covers only 1.5% of human 3 billion base pairs carrying the genetic information,and over 98 percent of genetic information does not directly encode the proteins. In recent years,with the rapid development of sequencing technology,it is found that genetic information of non-protein-coding genes is closely related to regulation,slicing,transcription and other biological processes. Long non-coding RNA（lncRNA）regulates the critical life processes such as epigenetic regulation,transcriptional regulation,disease control,cell differentiation,and individual development,thus it become an extremely crucial issue that how to seek the RNA functional units and predict the novel long non-coding RNA. In this review,we summarize the origin and evolution of lncRNA,the functioning in cancer biology,and some common database of lncRNA,as well as using the latest bioinformatics tools and related technologies to predict lncRNAs for further functional studies.

Key words: lncRNA, cancer, database, bioinformatics

SONG Na-na, CHAI Zhi-xin, ZHONG Jin-cheng. Research Advances on Long Non-coding RNA[J]. Biotechnology Bulletin, 2016, 32(9): 23-31.

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