Research Progress on Whole-genome Sequencing on Important Domesticated Animals

doi:10.13560/j.cnki.biotech.bull.1985.2017-0719

Abstract

Abstract: Whole-genome sequencing mainly refers to obtain the full genome sequence map of a species through different sequencing and assembly alignment method，and based on it to explore their genetic diversity，selection signal，and the origin and evolution of representative individuals or groups by constructing whole-genome genetic variation map. Using single nucleotide polymorphism（SNP），insertion and deletion（Indel）and copy number variation（CNV）genetic variation as molecular markers，the studies on whole-genome sequencing has been achieved a lot in the origin and evolution of domestic animal，domestication，adaptive mechanism，candidate genes for important economic traits，and population demographic. This paper focuses on the key achievements of whole-genome sequencing on common domesticated animals（such as pig，horse，cattle，sheep，goat，and closely-related species），and discusses the advantages，disadvantages and significance of whole-genome sequencing in production. In addition，this paper summarizes and prospects the future development of researches on whole-genome sequencing. And we also hope to provide a reference for mapping functional genes with important economic traits and the origin domestication of domesticated animals.

Key words: whole-genome sequencing, genetic variation, functional gene, single-nucleotide polymorphism

LI Xiao-kai ,WANG Gui ,QIAO Xian ,FAN Yi-xing ,ZHANG Lei ,MA Yu-hao ,NIE Rui-xue ,WANG Rui-jun ,HE Li-bing ,SU Rui. Research Progress on Whole-genome Sequencing on Important Domesticated Animals[J]. Biotechnology Bulletin, 2018, 34(6): 11-21.

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