Applications of Riboswitch-based Novel Regulation System of Gene Expression

doi:10.13560/j.cnki.biotech.bull.1985.2017.02.006

Abstract

Abstract: Riboswitches are cis-acting elements that can respond to the environmental changes of the cell by altering its conformation to achieve the regulation of gene expression. Due to its characteristics of simple regulation system without proteins involved,response fast,short sequences with simple structure,and easy to design and modify,applying it in biomedical area should be in superiority. The review addresses the advance of the structure and regulation mechanism of riboswitches,as well as the applications of this novel regulation system of gene expression in gene therapy,the development of novel target for antibiotic,the safety switch for virus vaccine,and the new riboselectors and biosensors,aiming at inspiring the application of riboswitches in China.

Key words: riboswitch, regulation system of gene expression, mechanism

XIONG Ying-zhe, CAO Yuan-qin, XIAO Ling-hui, LI Zhao-fa. Applications of Riboswitch-based Novel Regulation System of Gene Expression[J]. Biotechnology Bulletin, 2017, 33(2): 41-46.

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