Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (2): 289-296.doi: 10.13560/j.cnki.biotech.bull.1985.2021-1600s
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GUO Xiao-zhen(
), ZHANG Xue-fu()
Received:2021-07-10
Online:2022-02-26
Published:2022-03-09
Contact:
ZHANG Xue-fu
E-mail:937054577@qq.com;zhangxuefu@caas.cn
GUO Xiao-zhen, ZHANG Xue-fu. Analysis of the Development Trend in the Field of Plant Synthetic Biology[J]. Biotechnology Bulletin, 2022, 38(2): 289-296.
| 启动时间 Start-up time | 项目名称 Project |
|---|---|
| 2011年 | 人工合成细胞工厂 |
| 光合作用与人工叶片 | |
| 2012年 | 新功能人造生物器件的构建与集成 |
| 微生物药物创新与优产的人工合成体系 | |
| 用合成生物学方法构建生物基材料的合成新途径 | |
| 2013年 | 合成微生物体系的适配性研究 |
| 抗逆元器件的构建和机理研究 | |
| 2014年 | 合成生物器件干预膀胱癌的研究 |
| 微生物多细胞体系的设计与合成 | |
| 2015年 | 生物固氮及相关抗逆模块的人工设计与系统优化 |
Table 1 Synthetic biology related projects supported by “973” program
| 启动时间 Start-up time | 项目名称 Project |
|---|---|
| 2011年 | 人工合成细胞工厂 |
| 光合作用与人工叶片 | |
| 2012年 | 新功能人造生物器件的构建与集成 |
| 微生物药物创新与优产的人工合成体系 | |
| 用合成生物学方法构建生物基材料的合成新途径 | |
| 2013年 | 合成微生物体系的适配性研究 |
| 抗逆元器件的构建和机理研究 | |
| 2014年 | 合成生物器件干预膀胱癌的研究 |
| 微生物多细胞体系的设计与合成 | |
| 2015年 | 生物固氮及相关抗逆模块的人工设计与系统优化 |
Fig. 1 Time distribution of cumulative published articles in synthetic biology field
Fig. 2 Time distribution diagram of published amount and growth amount of literature in synthetic biology field
Fig. 3 Co-occurrence map of keywords in synthetic biology from year 2005 to 2009
Fig. 4 Co-occurrence map of keywords in synthetic biology from year 2005 to 2009
Fig. 5 Co-occurrence map of keywords in synthetic biology from year 2015 to 2019
Fig. 6 Citation network in the field of plant synthetic biology from year 2000 to 2019
| 节点 | 内容解读 |
|---|---|
| Wittstock U（2000） | Cytochrome P450CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate |
| Mikkelsen MD（2000） | Cytochrome P450CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime,a precursor of indole glucosinolates and indole-3-acetic acid |
| Hansen CH（2001） | Cytochrome P450CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates |
| Mikkelsen MD（2003） | Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways |
| Mikkelsen MD（2004） | Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis |
| Grubb CD（2004） | Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis |
| Levy M（2005） | Arabidopsis IQD1,a novel calmodulin-binding nuclear protein,stimulates glucosinolate accumulation and plant defense |
| Skirycz A（2006） | DOF transcription factor AtDof1.1（OBP2）is part of a regulatory network controlling glucosinolate biosynthesis in Arabidopsis |
| Gigolashvili T（2007） | The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana |
| Sonderby IE（2007） | A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates |
| Malitsky S（2008） | The transcript and metabolite networks affected by the two clades of Arabidopsis glucosinolate biosynthesis regulators |
| Sawada Y（2009） | Omics-Based approaches to methionine side chain elongation in Arabidopsis：Characterization of the genes encoding methylthioalkylmalate isomerase and methylthioalkylmalate dehydrogenase |
| Sawada Y（2009） | Arabidopsis bile acid：sodium symporter family protein 5 is involved in methionine-derived glucosinolate biosynthesis |
| Albinsky D（2010） | Widely targeted metabolomics and coexpression analysis as tools to identify genes involved in the side-chain elongation steps of aliphatic glucosinolate biosynthesis |
| Sonderby IE（2010） | A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis1[C][W][OA] |
| Pfalz M（2011） | Metabolic engineering in nicotiana benthamiana reveals key enzyme functions in Arabidopsis indole glucosinolate modification |
| Mikkelsen MD（2012） | Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform |
| Fossati E（2014） | Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae |
| Trenchard IJ（2015） | De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast |
| DeLoache WC（2015） | An enzyme-coupled biosensor enables（S）-reticuline production in yeast from glucose |
| Galanie S（2015） | Optimization of yeast-based production of medicinal protoberberine alkaloids |
| Li YR（2018） | Complete biosynthesis of noscapine and halogenated alkaloids in yeast |
| Wang Y（2019） | Design and use of de novo cascades for the biosynthesis of new benzylisoquinoline alkaloids |
| Cabry MP（2019） | Structure of Papaver somniferum O-methyltransferase 1 reveals initiation of noscapine biosynthesis with implications for plant natural product methylation |
| Lang DE（2019） | Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition |
Table 2 Content analysis of main path nodes in year 2010-2019
| 节点 | 内容解读 |
|---|---|
| Wittstock U（2000） | Cytochrome P450CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate |
| Mikkelsen MD（2000） | Cytochrome P450CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime,a precursor of indole glucosinolates and indole-3-acetic acid |
| Hansen CH（2001） | Cytochrome P450CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates |
| Mikkelsen MD（2003） | Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways |
| Mikkelsen MD（2004） | Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis |
| Grubb CD（2004） | Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis |
| Levy M（2005） | Arabidopsis IQD1,a novel calmodulin-binding nuclear protein,stimulates glucosinolate accumulation and plant defense |
| Skirycz A（2006） | DOF transcription factor AtDof1.1（OBP2）is part of a regulatory network controlling glucosinolate biosynthesis in Arabidopsis |
| Gigolashvili T（2007） | The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana |
| Sonderby IE（2007） | A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates |
| Malitsky S（2008） | The transcript and metabolite networks affected by the two clades of Arabidopsis glucosinolate biosynthesis regulators |
| Sawada Y（2009） | Omics-Based approaches to methionine side chain elongation in Arabidopsis：Characterization of the genes encoding methylthioalkylmalate isomerase and methylthioalkylmalate dehydrogenase |
| Sawada Y（2009） | Arabidopsis bile acid：sodium symporter family protein 5 is involved in methionine-derived glucosinolate biosynthesis |
| Albinsky D（2010） | Widely targeted metabolomics and coexpression analysis as tools to identify genes involved in the side-chain elongation steps of aliphatic glucosinolate biosynthesis |
| Sonderby IE（2010） | A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis1[C][W][OA] |
| Pfalz M（2011） | Metabolic engineering in nicotiana benthamiana reveals key enzyme functions in Arabidopsis indole glucosinolate modification |
| Mikkelsen MD（2012） | Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform |
| Fossati E（2014） | Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae |
| Trenchard IJ（2015） | De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast |
| DeLoache WC（2015） | An enzyme-coupled biosensor enables（S）-reticuline production in yeast from glucose |
| Galanie S（2015） | Optimization of yeast-based production of medicinal protoberberine alkaloids |
| Li YR（2018） | Complete biosynthesis of noscapine and halogenated alkaloids in yeast |
| Wang Y（2019） | Design and use of de novo cascades for the biosynthesis of new benzylisoquinoline alkaloids |
| Cabry MP（2019） | Structure of Papaver somniferum O-methyltransferase 1 reveals initiation of noscapine biosynthesis with implications for plant natural product methylation |
| Lang DE（2019） | Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition |
Fig.7 Key nodes obtained by main path analysis method from year 2000 to 2009
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