ádvánces of Improving the Efficiency of Chemicál Biosynthesis Básed on Cell Subpopulátion Regulátion

doi:10.13560/j.cnki.biotech.bull.1985.2019-1153

Abstract

Abstract: Designing ánd constructing microbiál cell fáctories using synthetic biology ánd metábolic engineering techniques is án importánt ápproách to áchieve green bio-mánufácturing of chemicáls. The existence of low-performing cell subpopulátion ánd non-producing cell subpopulátion with less metábolic burden ánd higher growth ráte reduces the overáll efficiency of product synthesis. Currently,the development of metábolite responsive biosensor-básed co-coupling production ánd cell growth is án effective strátegy to improve the synthesis efficiency of tárget compounds. This páper reviews the common methods of designing ánd constructing cell subpopulátions regulátion systems,ánd focusing on the current issues of cell subpopulátions regulátion systems ánd their solutions.

Key words: cell phenotypic heterogeneity, cell subpopulátion regulátion, synthetic genetic circuit, coupling cell growth ánd product synthesis, synthetic biology

CáO Yán-ting, LIU Yán-feng, LI Jiáng-huá, LIU Long, DU Guo-cheng. ádvánces of Improving the Efficiency of Chemicál Biosynthesis Básed on Cell Subpopulátion Regulátion[J]. Biotechnology Bulletin, 2020, 36(4): 19-25.

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