Abstract:

Prohibitin（PHB）, a highly-conserved protein, widely distributed and functional diversity, is encoded by the nuclear genes and located in nucleus membranes, mitochondrial membrane substrates and matrixes. It has been paid high attention because of its participation in a variety of biological processes. Now it is becoming a new research hotpot, because the special position on the mitochondrial and its special structure and function on it. In accordance with the studies of the relation of PHB and mitochondrial, PHB's important role was systematically elaborated in oxidative stress and the related diseases and the process of ageing in this paper, and the PHB's prospect of application was also looked into the future.

Key words: PHB, Mitochondria, Oxidative stress, Disease