RhoGEF Family and the Role in Occurrence and Development of Diseases

Abstract

Abstract: Rho GTPases family plays a role of molecular switch in many cellular processes, including cytoskeletal dynamics, vesicle trafficking and gene transcription. Guanine nucleotide exchange factors(RhoGEFs)are the key regulator of activity for Rho GTPases. RhoGEFs can regulate signal transduction of Rho GTPases, development of tissues or organs and immune response. RhoGEFs are associated with cancer,development or neural system related diseases and pathogen infection, understanding of its function will help us to verify the mechanisms of some physiological and pathological process.

Key words: Rho, GTPase, Guanine nucleotide exchange factors(GEFs), Disease occurrence

Liu Mingtao, Yang Jun, Wang Zhigang. RhoGEF Family and the Role in Occurrence and Development of Diseases[J]. Biotechnology Bulletin, 2014, 0(1): 63-67.

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