Research Progress on p53-involved Metabolic Regulation

doi:10.13560/j.cnki.biotech.bull.1985.2016.11.007

Abstract

Abstract: As a tumor suppressor,p53 not only is involved in the stress regulation of genetic toxicity,but also plays an important role in the regulation of metabolic balance. When the cells are in different physiological stresses,the activated p53 will affect various metabolic pathways by participating in the regulations of glucose metabolism,fatty acid metabolism,and ROS level. Consequently,the metabolic stress was generated by firstly inducing the occurrence of cell cycle arrest,repair,senescence or apoptosis and finally regulating the organisms and cells. This review summarized the current advances of p53 pathxxray, and discussed the role that p53 played in cancer and metabolic syndrome, which might benefit the study of p53 involved in metabolic regulation.

Key words: p53, metabolic stress, energy metabolism, metabolic regulation

CHEN Ke, DING Yan-ping, WANG Jian-lin, SHAO Bao-ping. Research Progress on p53-involved Metabolic Regulation[J]. Biotechnology Bulletin, 2016, 32(11): 52-58.

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