Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (1): 247-257.doi: 10.13560/j.cnki.biotech.bull.1985.2021-0217

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Advances in Extrachromosomal Circular DNA and Their Application in Domestic Animal Breeding

CAO Xiu-kai1(), WANG Shan2, GE Ling2, ZHANG Wei-bo2, SUN Wei1,2()   

  1. 1. Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China,Yangzhou University,Yangzhou 225009
    2. College of Animal Science and Technology,Yangzhou University,Yangzhou 225009
  • Received:2021-02-25 Online:2022-01-26 Published:2022-02-22
  • Contact: SUN Wei E-mail:cxkai0909@163.com;dkxmsunwei@163.com

Abstract:

Extrachromosomal circular DNA(eccDNA),exiting as double-stranded circular DNA,arise from and are outside of chromosome. They are common in eukaryote,but have strong heterogeneity in count,length,origin,which lead to functional diversity,including telomere prolonging,rDNA copy number maintenance,aging,drug resistance,tumorigenesis. The associations between eccDNA and domestic animal phenotypes have been reported as well. Here,we review the current knowledge related to eccDNA classification,biogenesis,functions,and identification,and discuss some possible future directions of eccDNA applications in animal breeding.

Key words: eccDNA, ecDNA, high-throughput sequencing, molecular marker, animal breeding