Biotechnology Bulletin ›› 2023, Vol. 39 ›› Issue (6): 126-132.doi: 10.13560/j.cnki.biotech.bull.1985.2022-0860

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Progress in Selection and Application of Antibacterial Aptamers

LI Dian-dian1(), SU Yuan1, LI Jie2, XU Wen-tao1, ZHU Long-jiao1()   

  1. 1. Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083
    2. Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, Faculty of Food Science and Engineering, Beijing University of Agriculture, Beijing 102206
  • Received:2022-07-11 Online:2023-06-26 Published:2023-07-07
  • Contact: ZHU Long-jiao E-mail:3219435892@qq.com;zhulongjiao@cau.edu.cn

Abstract:

One of the major challenges in modern medicine and molecular biotechnology is to explore new therapeutic options for bacterial infections. The increasing rates of multidrug-resistant bacteria, overlaid with the efficacy, development process, and cost of antimicrobial agents, has made the treatments of bacterial infections even more challenging. In response to this situation, the most promising solution is to find alternative sources of antibacterial drugs, and antibacterial aptamers obtained through SELEX screening are promising alternatives. Antibacterial aptamers can reduce the pathogenic abilities of bacteria by interfering with the biochemical processes of bacteria, controlling the formations of bacterial membrane and blocking the infections of toxins. Currently, aptamer-based antibacterial strategies mainly include single aptamer antibacteria, aptamer composite nanomaterials, aptamer composite antibiotics, etc. In this paper, the screening strategies of aptamers for common pathogenic cells or their related components are summarized, and the adaptation and modification of aptamers are discussed from the aspects of antimicrobial mechanism and its application in antimicrobial therapy. The development prospect of antimicrobial strategies based on antibacterial aptamers in the treatment of infection is prospected, aiming to provide new ideas for the diagnosis and treatment of infectious diseases caused by pathogenic bacteria.

Key words: antibacterial aptamer, selection, bacteriostatic mechanism